Palladium-Catalyzed Asymmetric Domino Heck/Carbocyclization/Suzuki Reaction:A Dearomatization of Nonactivated Naphthalenes  

作　　者：Ming Chen Xucai Wang Zhi-Hui Ren Zheng-Hui Guan 

机构地区：[1]Key Laboratory of Synthetic and Nature Molecule of Ministry of Education,Department of Chemistry and Materials Science,Northwest University,Xi’an 710127

出　　处：《CCS Chemistry》2021年第12期69-77,共9页中国化学会会刊（英文）

基　　金：supported by generous grants from the National Natural Science Foundation of China(nos.NSFC-21971204,21622203,and 21702161);the Innovation Capability Support Program of Shaanxi Province(no.2020TD-022).

摘　　要：Herein,we report a novel palladium(Pd)-catalyzed asymmetric domino Heck/carbocyclization/Suzuki reaction of N-(2-bromoaryl)-2-naphthylacrylamides.The reaction involves a novel and enantioselective dearomative 1,2-insertion of the naphthalene group,thus providing a unique dearomatization strategy of nonactivated naphthalenes.A new phosphoramidite ligand L12,which displayed excellent reactivity and enantioselectivity in the reaction,has been developed.

关 键 词：asymmetric catalysis PALLADIUM-CATALYZED domino Heck reaction DEAROMATIZATION nonactivated naphthalenes 

分 类 号：O62[理学—有机化学]