克莱恩-莱文综合征1例  

Kleine-Levin syndrome:A case report

作　　者：朱孟霞 李菲菲[1] 衣香明[2] 马文彬[2] ZHU Mengxia;LI Feifei;YI Xiangming;MA Wenbin(Department of Neu-rology,Binzhou Medical University Hospital,Binzhou 256600)

机构地区：[1]滨州医学院附属医院癫痫中心,滨州256600 [2]滨州医学院附属医院神经内科

出　　处：《中国神经精神疾病杂志》2022年第10期629-631,共3页Chinese Journal of Nervous and Mental Diseases

基　　金：山东省医药卫生科技发展计划(编号:2019WS328)。

摘　　要：克莱恩-莱文综合征(Kleine-Levin syndrome,KLS)是一种罕见的复发-缓解周期性过度嗜睡疾病。本文总结分析了我院2022年5月收治的1例KLS患者临床资料,患者表现为典型的周期性睡眠增多,发作间期无症状体征,给予患者完善视频多导睡眠监测、多次睡眠潜伏期试验及基因检测后明确诊断,未给予特殊治疗患者出院,随访临床症状好转。本文旨在提高临床工作者对KLS的识别和认识,避免对周期性过度嗜睡患者的误诊漏诊,对该病的早期诊断和治疗具有重要意义。Kleine-Levin syndrome(KLS)is a rare,relapsing-remitting disease characterized by periodic hypersomnia.In this paper,the clinical data of a patient with KLS admitted to hospital in May 2022 was summarized and analyzed.The patient showed typical periodic hypersomnia,no signs and symptoms during the interictal period,and the patient was given a clear diagnosis after video polysomnography(vPSG)monitoring,multiple sleep latency tests(MSLT)and genetic testing,and the patient was discharged without special treatment,and clinical symptoms improved during follow up.This case reported could improve the awareness of KLS and avoid its misdiagnosis and missed diagnosis among clinicians,which will be of great significance for the early diagnosis and treatment of the disease.

关 键 词：克莱恩-莱文综合征 嗜睡 视频多导睡眠监测 多次睡眠潜伏期试验 基因检测 诊断 治疗 

分 类 号：R741[医药卫生—神经病学与精神病学]