眼眶淋巴瘤的病因及发病机制研究进展  

Advances in etiology and pathogenesis of orbital lymphoma

作　　者：孙梅(综述) 马建民(审校) Sun Mei;Ma Jianmin(Department of Ophthalmology,Beijing Tongren Hospital,Capital Medical University,Beijing Tongren Eye Center,Beijing Ophthalmology&Vision Science Key Lab,Beijing 100730,China)

机构地区：[1]首都医科大学附属北京同仁医院眼科、北京同仁眼科中心、北京市眼科学与视觉科学重点实验室,北京100730

出　　处：《中华实验眼科杂志》2022年第11期1108-1113,共6页Chinese Journal Of Experimental Ophthalmology

基　　金：国家自然科学基金项目(81371052);北京市自然科学基金项目(722205)。

摘　　要：眼眶淋巴瘤(OLs)是眼附属器常见的恶性肿瘤。根据异常增生淋巴细胞来源的不同,OLs可进一步分为多种亚型,其病因和发病机制尚存在争议。目前,OLs的病因及发病机制主要与淋巴细胞遗传异常、免疫抑制异常、自身免疫性疾病以及慢性抗原性刺激4个方面有关。但由于眼部没有真正的淋巴引流系统,只具有从泪腺延伸到结膜和泪道的粘膜相关淋巴组织(MALT)系统,OLs的发病机制具有一定的特性;且不同亚型OLs的病因差异较大,如不同的染色体畸变可造成不同亚型的OLs,在不同自身免疫性疾病中各OLs亚型倾向不同等。本文对国内外OLs的病因及发病机制的研究做一综述,以期为临床对该病的诊断及治疗提供参考。Orbital lymphomas(OLs)are the common malignant tumor of the ocular adnexa.According to the source of abnormally proliferating lymphocytes,OLs can be further divided into several subtypes.The etiology and pathogenesis of OLs are still controversial.The current researches on OLs have shown that the etiology and pathogenesis of the disease are mainly related to genetic abnormalities of lymphocytes,abnormal immunosuppression,autoimmune diseases and chronic antigenic stimulation.However,there is no real lymphatic drainage system in the eye.Only a mucosa-associated lymphoid tissue(MALT)system extends from the lacrimal glands to the conjunctiva and lacrimal duct,so the pathogenesis of OLs is still unique.And the etiology of different OLs subtypes is quite different.For example,different chromosomal aberrations can cause varying subtypes of OLs,and various OLs subtypes have diverse predispositions in different autoimmune diseases.Researches on the etiology and pathogenesis of OLs at home and abroad were reviewed in this article to provide a reference for its clinical diagnosis and treatment.

关 键 词：眼眶淋巴瘤 细胞遗传 免疫 抗原 

分 类 号：R739.7[医药卫生—肿瘤]