Bai Hu Ren Shen Soup promotes autophagy in the pancreas tissue of diabetic rats by increasing the level of autophagy protein LC3 and decreasing the level of autophagy protein p62  

作　　者：Shu-Quan Lv Bao-Chao Pan Bin Yao Tian Tian Xiu-Hai Su Shu-Fang Zhang Han-Zhou Li Wen-Juan Sun Tian-Yu Zhang Hui Zhang 

机构地区：[1]Department of Endocrinology,Cangzhou Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Hebei University of Traditional Chinese Medicine,Cangzhou 061001,China [2]Graduate School,Hebei University of Traditional Chinese Medicine,Shijiazhuang 050091,China [3]Graduate School,Chengde Medical College,Chengde 067000,China

出　　处：《Life Research》2023年第1期17-21,共5页TMR生命研究

摘　　要：Objective:To investigate the therapeutic effect of Bai Hu Ren Shen Soup(BHRSS)on type 2 diabetes mellitus(T2DM)rats and explore whether its therapeutic effect is achieved by promoting autophagy in the pancreas tissue of T2DM rats.Methods:Thirty male standard deviation rats were equally divided into normal control group,T2DM group and BHRSS group.Firstly,the therapeutic effect of BHRSS on T2DM was evaluated by biochemical indices in serum and pathological changes in the pancreas tissue of rats in each group after modeling and medication.Then,the levels of microtubule-associated protein 1 light chain 3(LC3)protein and p62 protein in the pancreas tissue of rats in each group after BHRSS intervention were detected by Western blot.Results:BHRSS intervention significantly reduced the levels of blood sugar,liver and kidney function,and other related biochemical indices in the serum of T2DM rats,and effectively improved the pathological changes in the pancreas tissue of T2DM rats.In addition,Western blot results showed that the expression levels of autophagy-related protein LC3 protein in the pancreas tissue of rats were increased,and the expression level of p62 protein was decreased after BHRSS intervention.Conclusion:BHRSS has a clear therapeutic effect on T2DM model rats,which may be related to that increase of autophagy protein LC3 and the decrease of p62 protein level in the pancreas tissue.

关 键 词：Bai Hu Ren Shen Soup type 2 diabetes mellitus pancreas tissue AUTOPHAGY 

分 类 号：R73[医药卫生—肿瘤]