Extension Protocol for the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC)Study:2021 update  

作　　者：Hong Xia Xu Chun Hua Song Liang Yu Yin Chang Wang Zhen Ming Fu Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Zhi Kang Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Xiang Hua Wu Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Ya Yin Yu Quan Jun Lyu Hong Qiu Ming Liu Wei Li Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group 

机构地区：[1]Department of Nutrition,Daping Hospital,Army Medical University(Third Military Medical University),Chongqing 400042,China [2]Department of Epidemiology,College of Public Health,Zhengzhou University,Zhengzhou 450001,Henan,China [3]Cancer Center of the First Hospital of Jilin University,Changchun 130021,Jilin China [4]Cancer Center,Renmin Hospital of Wuhan University,Wuhan 430060,Hubei,China [5]Department of Medical Oncology,Fujian Cancer Hospital,Fujian Medical University Cancer Hospital,Fuzhou 350014,Fujian,China [6]Department of Gastrointestinal Surgery,Affiliated Tumor Hospital of Guangxi Medical University,Nanning 530021,Guangxi,China [7]Department of Surgery,The First Affiliated Hospital of SunYat-Sen University,Guangzhou 510080,Guangdong,China [8]Department of Clinical Nutrition,West China Hospital of Sichuan University,Chengdu 610041,Sichuan,China [9]Department of Gastrointestinal Oncology,Tianjin Medical University Cancer Institute and Hospital,National Clinical Research Center for Cancer,Tianjin Key Laboratory of Cancer Prevention and Therapy,Tianjin 300060,China [10]Department of Nutrition and Metabolism of Oncology,The First Affiliated Hospital of University of Science and Technology of China,Anhui Provincial Cancer Hospital,Hefei 230031,Anhui,China [11]Department of Clinical Nutrition,The First Hospital of Hebei Medical University,Shijiazhuang 050031,Hebei,China [12]Department of Gastrointestinal Surgery,Institute of Gastroenterology,The First Affiliated Hospital of Kunming Medical University,Kunming 650032,Yunnan,China [13]Department of Clinical Nutrition,The First Affiliated Hospital of Zhejiang Chinese Medical University,Zhejiang Provincial Hospital of Traditional Chinese Medicine,Hangzhou 310006,Zhejiang,China [14]Department of Clinical Nutrition,Chongqing General Hospital,Chongqing 400014,China [15]Department of Colorectal and Anal Surgery,Huizhou Municipal Central Hospital,Huizhou 516001,Guangdong,China [16]Department of Radiation and Medical Oncology,Zhongnan Hospital of Wuhan University,Wuha

出　　处：《Journal of Nutritional Oncology》2022年第2期64-74,共11页肿瘤营养学杂志（英文）

基　　金：the Talent Innovation Capacity Development Program of Army Medical Center of PLA(2019CXJSC003,to Hong Xia Xu);Beijing Municipal Science and Technology Commission(SCW2018-06 to Han Ping Shi);the National Key Research and Development Program(No.2017YFC1309200 to Han Ping Shi).

摘　　要：Background Malnutrition is common in patients with cancer,and this adversely affects the survival and quality of life of patients.Chinese Society for Nutritional Oncology issued a multi-center,large-scale,long-term follow-up prospective study,the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC study)since 2013.This is an extension to the previous 2013-2020 study protocol.This study still sought to:①address the prognostic impact of nutritional factors and quality of life on cancer patient survival;②describe the overall and cancer-specific incidence and/or distribution of malnutrition and different measurements of patient quality of life.Methods and study design This is an observational,multi-centered,hospital-based prospective cohort study.Data collection will be performed at baseline(within 48 hours after patient admission),during the hospital stay and 30 days after hospital admission.Follow-up will be conducted for 1-20 years after enrollment.The primary outcome will be the all-cause mortality/overall survival,and secondary outcomes will be the length of hospital stay and costs of hospitalization.Study factors will include demographic characteristics,tumor characteristics,information about chronic diseases,hematological measurements(e.g.,red blood cell count,total lymphocyte counts,hemoglobin,albumin,prealbumin,creatinine,C-reactive protein,IL-6),anthropometric measurements(e.g.,height,weight,arm circumference,arm muscle circumference,triceps skinfold thickness,and waist circumference),body composition parameters,PG-SGA scores,quality of life(as indicated by the QLQ-C30 questionnaire),muscle mass(as indicated by the calf circumference),muscle strength(as indicated by the handgrip strength),muscle function(as indicated by the six-meter walking speed test)and physical status assessments(as indicated by the Karnofsky Performance Status scores).This clinical study protocol was approved by local Ethics Committees of all the participating hospitals.Written inf

关 键 词：Cancer MALNUTRITION Nutritional status Nutritional assessment SURVIVAL Patient-Generated Subjective Global Assessment 

分 类 号：R730.5[医药卫生—肿瘤] R459.3[医药卫生—临床医学]