Associations of the Fat-age-infl ammation Index with Overall Survival in Patients with Metastatic Lung Cancer  

作　　者：Na Li Yu Jun Zhang Chuan Chen Wei Li Chun Hua Song Han Ping Shi Hong Xia Xu Liang Yu Yin 

机构地区：[1]Department of Clinical Nutrition,Daping Hospital,Army Medical University(Third Military Medical University),Chongqing 400042,China [2]Institute of Hepatopancreatobiliary Surgery,Southwest Hospital,Army Medical University(Third Military Medical University),Chongqing 400038,China [3]Department of Cancer Center,Daping Hospital,Army Medical University(Third Military Medical University),Chongqing 400042,China [4]Cancer Center of the First Hospital of Jilin University,Changchun,Jilin 130021,China [5]Department of Epidemiology,College of Public Health,Zhengzhou University,Zhengzhou,Henan 450001,China [6]Department of Gastrointestinal Surgery and Department of Clinical Nutrition,Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China

出　　处：《Journal of Nutritional Oncology》2022年第2期85-93,共9页肿瘤营养学杂志（英文）

基　　金：the Talent Innovation Capacity Development Program of Army Medical Center of PLA(2019CXJSC003,to Hong Xia Xu);National Key Research and Development Program(2017YFC1309200).

摘　　要：Background Metastatic lung cancer(LC)is a threat to human health.We previously proposed a fat age-inflammation(FAIN)index which showed prognostic value in patients with certain cancers.However,whether a similar association exists in patients with metastatic LC remains unknown.Methods We performed a cohort study including 1360 patients with metastatic LC from January 2013 to April 2019.The FAIN index was defined as:(triceps skinfold thickness+albumin)/[age+5×(neutrophil count/lymphocyte count)]×100%.Sex-specific cutoffs of the FAIN were determined using an optimal stratification approach.The associations of the FAIN index with the nutrition related factors,short-term outcomes and overall survival(OS)of patients were comprehensively assessed.Results The study enrolled 865 males and 495 females with a median age of 59.9 years.The continuous FAIN was significantly associated with the OS in both genders(both P<0.05).The optimal stratification-defined FAIN cutoffs were 82 for women and 60 for men.A total of 623 patients(45.8%)were categorized as having a low FAIN.A low FAIN was associated with poorer nutrition-related factors and impaired short-term outcomes including the thirty-day mortality,length of hospital stay,intensive care unit stay and cost(all P<0.05).Multivariate Cox regression analysis revealed that a lower FAIN was also associated with an increased death hazard(HR=1.428,95%CI=1.209-1.686).Conclusion This study assessed the FAIN index,which might act as a feasible tool to monitor nutrition-related factors and help develop management strategies to optimize the clinical outcomes of patients with metastatic LC.

关 键 词：Metastatic lung cancer MALNUTRITION Fat-age-inflammation SURVIVAL 

分 类 号：R734.2[医药卫生—肿瘤]