我国膳食无机砷致癌症及心血管疾病的疾病模型构建  

Construction of disease models for cancer and cardiovascular disease induced by dietary inorganic arsenic in China

作　　者：李依玲 刘佳琳 黄娇 王彝白纳 魏晟[1] LI Yiling;LIU Jialin;HUANG Jiao;WANG Yibaina;WEI Sheng(Department of Epidemiology and Biostatistics,School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Hubei Wuhan 430030,China;Center for Evidence-Based and Translational Medicine,Zhongnan Hospital of Wuhan University,Hubei Wuhan 430071,China;Key Laboratory of Food Safety Risk Assessment,Ministry of Health,National Food Safety Risk Assessment Center,Beijing 100022,China)

机构地区：[1]华中科技大学同济医学院公共卫生学院流行病与卫生统计学系,湖北武汉430030 [2]武汉大学中南医院循证与转化医学中心,湖北武汉430071 [3]国家食品安全风险评估中心卫生部食品安全风险评估重点实验室,北京100022

出　　处：《中国食品卫生杂志》2022年第5期974-981,共8页Chinese Journal of Food Hygiene

基　　金：国家重点研究发展计划(2018YFC1603105)。

摘　　要：目的 构建我国膳食无机砷致癌症及心血管疾病的疾病模型。方法 首先确立膳食无机砷导致的不同健康危害终点。根据我国人群相关疾病的流行病学数据,分别采用风险评估法和反事实分析法计算膳食无机砷暴露致癌症及心血管疾病的归因发病率、死亡率,结合疾病的伤残权重及病程等特点,构建膳食无机砷暴露致癌症及心血管疾病的疾病模型。结果 人群终身持续经膳食暴露于1.41μg/(kg·d)无机砷时,引起皮肤癌、膀胱癌和肺癌的发病率分别为0.135%、0.010%以及0.034%,死亡率分别为0.015%、0.004%以及0.138%。人群终身持续经膳食暴露于1μg/(kg·d)无机砷时,引起的心血管疾病发病率及死亡率分别为0.082%、0.025%。结论 疾病模型可用于计算食品污染物导致的疾病负担,对食品污染物的健康危害进行量化。ObjectiveTo construct disease models of dietary inorganic arsenic-induced cancer and cardiovascular disease in China.MethodsThe different health hazard endpoints due to dietary inorganic arsenic should be identified.Based on the epidemiological data of related diseases in the Chinese population,the risk assessment method and counterfactual analysis method were used to calculate the attributable morbidity and mortality of cancer and cardiovascular disease caused by dietary inorganic arsenic exposure. Combined with disability weight and disease course characteristics,a disease model of cancer and cardiovascular disease caused by dietary inorganic arsenic exposure was established.ResultsLifetime persistent dietary exposure to 1. 41 μg/(kg · d) of inorganic arsenic in the population resulted in0. 135%,0. 010% and 0. 034% of skin,bladder,and lung cancer incidence with 0. 015%,0. 004% and 0. 138% of mortality,respectively. The incidence and mortality of cardiovascular diseases caused by 1 μg/(kg·d)of dietary inorganic arsenic exposure were 0. 082% and 0. 025%,respectively.ConclusionThe disease model can be used to calculate the burden of disease caused by food contaminants and quantify the health hazards caused by food contaminants.

关 键 词：食品污染 无机砷 疾病模型 

分 类 号：R155[医药卫生—营养与食品卫生学]