Copper-Catalyzed Highly Enantioselective 1,4-Protoboration of Terminal 1,3-Dienes  

作　　者：Qitao Guan Yuqi Ji Qian Zhao Chun Zhang 

机构地区：[1]Institute of Molecular Plus,Tianjin Key Laboratory of Molecular Optoelectronic Science,Department of Chemistry,School of Science,Tianjin University,Tianjin 300072

出　　处：《CCS Chemistry》2022年第5期1545-1556,共12页中国化学会会刊（英文）

基　　金：a generous grant from Tianjin University,National Natural Science Foundation of China(no.21801181).

摘　　要：The copper-catalyzed,highly enantioselective 1,4-protoboration of terminal 1,3-dienes with proton source and B2Pin2 has been developed.Chiral allylic boronate reagents,which are significant precursors for many well-established transformations,were prepared by this novel method with good functional group tolerance and enantioselectivity.Further studies indicated the products could be used as versatile precursors for asymmetric transformations and natural products syntheses.The mechanism of this reaction was investigated by control and reaction monitoring experiments.

关 键 词：COPPER-CATALYZED ENANTIOSELECTIVITY regioselectivity conjugated addition chiral borated allylic reagents 

分 类 号：O62[理学—有机化学]