Photoacoustic viscoelasticity imaging dedicated to mechanical characterization of biological tissues  

作　　者：Yujiao Shi Fen Yang Qian Wang 

机构地区：[1]Ministry of Education Key Laboratory of Laser Life Science,College of Biophotonics,South China Normal University Guangzhou,510631,P.R.China [2]Institute of Laser Life Science,College of Biophotonics South China Normal University,Guangzhou 510631,P.R.China

出　　处：《Journal of Innovative Optical Health Sciences》2017年第4期29-41,共13页创新光学健康科学杂志（英文）

基　　金：the National Natural Science Foundation of China(Grant Nos.81630046,61627827,61331001 and 91539127);the Science and Technology Planning Project of Guangdong Province,China(Nos.2015B020233016,2014B020215003 and 2014A020215031);the Science and Technology Youth Talent for Special Program of Guangdong,China(Nos.2015TQ01X882);the Distinguished Young Teacher Project in Higher Education of Guangdong,China(No.YQ2015049).

摘　　要：Since changes in mechanical properties of biological tissues are often closely related to pathology,the viscoelastic properties are important physical parameters for medical diagnosis.A photoacoustic(PA)phase-resolved method for noninvasively characterizing the biological tissue viscoelasticity has been proposed by Gao et al.[G.Gao,S.Yang,D.Xing,\Viscoelasticity imaging of biological tissues with phase-resolved photoacoustic measurement,"Opt.Lett.36,3341–3343(2011)].The mathematical relationship between the PA phase delay and the viscosity–elasticity ratio has been theoretically deduced.Moreover,systems of PA viscoelasticity(PAVE)imaging including PAVE microscopy and PAVE endoscopy were developed,and high-PA-phase contrast images re°ecting the tissue viscoelasticity information have been successfully achieved.The PAVE method has been developed in tumor detection,atherosclerosis characterization and related vascular endoscopy.We reviewed the development of the PAVE technique and its applications in biomedical¯elds.It is believed that PAVE imaging is of great potential in both biomedical applications and clinical studies.

关 键 词：Photoacoustic imaging VISCOELASTICITY phase detection ATHEROSCLEROSIS 

分 类 号：R73[医药卫生—肿瘤]