New definition of metabolic dysfunction-associated fatty liver disease with elevated brachial-ankle pulse wave velocity and albuminuria: a prospective cohort study  

作　　者：Jialu Wang Shanshan Liu Qiuyu Cao Shujing Wu Jingya Niu Ruizhi Zheng Lizhan Bie Zhuojun Xin Yuanyue Zhu Shuangyuan Wang Hong Lin Tiange Wang Min Xu Jieli Lu Yuhong Chen Yiping Xu Weiqing Wang Guang Ning Yu Xu Mian Li Yufang Bi Zhiyun Zhao 

机构地区：[1]Department of Endocrine and Metabolic Diseases,Shanghai Institute of Endocrine and Metabolic Diseases,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China [2]Shanghai National Clinical Research Center for Metabolic Diseases,Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China,Shanghai Key Laboratory for Endocrine Tumor,State Key Laboratory of Medical Genomics,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China [3]Clinical Trials Center,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China

出　　处：《Frontiers of Medicine》2022年第5期714-722,共9页医学前沿（英文版）

基　　金：This work was supported by the grants from the National Key R&D Program of China(Nos.2017YFC1310700,2018YFC1311800,and 2018YFC1311705);the National Natural Science Foundation of China(Nos.81870560,82070880,81941017,81770842,81970706,and 82022011);the National Science and Technology Major Project for"Significant New Drugs Development"(No.2017ZX09304007);Shanghai Municipal Government(No.18411951800);Shanghai Shenkang Hospital Development Center(Nos.SHDC12019101,SHDC2020CR1001A,and SHDC2020CR3069B);the Scientific and Technological Committee of Shanghai(No.19411964200);Shanghai Jiao Tong University School of Medicine(No.DLY201801);Ruijin Hospital(No.2018 CR002);Shanghai Rising-Star Program(No.21QA1408100).

摘　　要：A new definition of metabolic dysfunction-associated fatty liver disease(MAFLD)has recently been proposed.We aim to examine the associations of MAFLD,particularly its discordance from non-alcoholic fatty liver disease(NAFLD),with the progression of elevated brachial-ankle pulse wave velocity(baPWV)and albuminuria in a community-based study sample in Shanghai,China.After 4.3 years of follow-up,778 participants developed elevated baPWV and 499 developed albuminuria.In comparison with the non-MAFLD group,the multivariable adjusted odds ratio(OR)of MAFLD group for new-onset elevated baPWV was 1.25(95%confidence interval(CI)1.01–1.55)and 1.35(95%CI 1.07–1.70)for albuminuria.Participants without NAFLD but diagnosed according to MAFLD definition were associated with higher risk of incident albuminuria(OR 1.77;95%CI 1.07–2.94).Patients with MAFLD with high value of hepamet fibrosis score or poor-controlled diabetes had higher risk of elevated baPWV or albuminuria.In conclusion,MAFLD was associated with new-onset elevated baPWV and albuminuria independently of body mass index,waist circumference,and hip circumference.Individuals without NAFLD but diagnosed as MAFLD had high risk of albuminuria,supporting that MAFLD criteria would be practical for the evaluation of long-term risk of subclinical atherosclerosis among fatty liver patients.

关 键 词：metabolic dysfunction-associated fatty liver disease non-alcoholic fatty liver disease fibrosis score brachial-ankle pulse wave velocity ALBUMINURIA 

分 类 号：R575.5[医药卫生—消化系统]