L-赖氨酸在晚期胃癌患者厌食及营养不良治疗中的疗效观察  

Therapeutic effect of L-lysine on anorexia and malnutrition in patients with advanced gastric cancer

作　　者：侯双雁[1] 林承雄[1] 黄世庆[2] 龙华[1] 叶婷[1] HOU Shuangyan;LIN Chengxiong;HUANG Shiqing;LONG Hua;YE Ting(Department of Nutrition,Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000,Guangxi,China;Chemotherapy Ward of Oncology Department,Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000,Guangxi,China)

机构地区：[1]右江民族医学院附属医院营养科,广西百色533000 [2]右江民族医学院附属医院肿瘤科化疗病区,广西百色533000

出　　处：《右江医学》2023年第1期47-50,共4页Chinese Youjiang Medical Journal

基　　金：百色市科学研究与技术开发计划项目(百科20192112)。

摘　　要：目的探讨L-赖氨酸在晚期胃癌患者厌食及营养不良治疗中的疗效。方法选取2020年1月至2021年5月在右江民族医学院附属医院诊治的晚期胃癌患者54例为研究对象,随机分为观察组和对照组。对照组(n=24)给予常规饮食指导和(或)肠内营养制剂,观察组(n=30)在对照组的基础上添加L-赖氨酸,连续治疗2个月。分别采用患者主观全面评估法(PG-SGA)评分及食欲视觉模拟评分评估两组治疗前及2个月后患者营养状况、厌食情况以及总蛋白、白蛋白、前白蛋白水平。结果治疗2个月后,两组患者PG-SGA评分均低于治疗前,食欲评分、血清总蛋白、白蛋白、前白蛋白水平均高于治疗前,差异有统计学意义(P<0.05),且观察组PG-SGA评分低于对照组,食欲评分、血清总蛋白、白蛋白、前白蛋白水平高于对照组,差异有统计学意义(P<0.05)。结论在晚期胃癌患者饮食中添加L-赖氨酸能有效提高患者食欲,促进营养物质吸收,从而改善患者的营养状态,但起效较慢,需要患者较长时间的配合。Objective To investigate the therapeutic effect of L-lysine on anorexia and malnutrition in patients with advanced gastric cancer.Methods 54 patients with advanced gastric cancer in Affiliated Hospital of Youjiang Medical University for Nationalities from January 2020 to May 2021 were selected as the subjects of study and randomly divided into study group(n=24)and control group(n=30).The control group were given routine dietary guidance and/or enteral nutrition,and the study group were given L-lysine on the basis of the control group for 2 months.The nutritional status,anorexia,levels of total protein,albumin and prealbumin in both groups before treatment and after 2 months of treatment were assessed by the Patient-Generated Subjective Global Assessment(PG-SGA)and appetite visual analogue scale(VAS).Results After 2 months of treatment,the PG-SGA scores of the two groups were lower than those before treatment,and the appetite VAS scores and levels of serum total protein,albumin and prealbumin were higher than those before treatment,and differences were statistically significant(P<0.05).After 2 months of treatment,the PG-SGA score of the study group was lower than that of the control group,and the appetite VAS score and levels of serum total protein,albumin and prealbumin in the study group were higher than those of the control group,and differences were statistically significant(P<0.05).Conclusion Adding L-lysine to the diet of patients with advanced gastric cancer can effectively improve the appetite of patients,promote the absorption of nutrients,and thus improve the nutritional status of patients.However,the effect is slow,and long-term cooperation of patients is required.

关 键 词：L-赖氨酸 晚期胃癌 厌食 营养不良 

分 类 号：R735.2[医药卫生—肿瘤] R459.3[医药卫生—临床医学]