Chemical identification,antioxidant,cholinesterase inhibitory,and cytotoxic properties of fucoidan extracted from Persian Gulf Sargassumangustifolium  

作　　者：Arghavan Hosseinpouri Mehdi Mohammadi Elham Ehsandoost Paria Sharafi-Badr Narges Obeidi 

机构地区：[1]Department of Cellular and Molecular Sciences,Faculty of Sciences,Persian Gulf University,Bushehr 75168,Iran [2]Department of Marine Biotechnology,Persian Gulf Institute,Persian Gulf University,Bushehr 75168,Iran [3]Department of Biotechnology,Persian Gulf Algae Development Technology,Delvar Industrial Zone No.55,Bushehr 75168,Iran [4]Department of Food Science and Technology,Shiraz University,Shiraz 71441-65186,Iran [5]Department of Pharmacognosy and Pharmaceutical Biotechnology,School of Pharmacy,Iran University of Medical Sciences,Tehran 14496-14535,Iran [6]Department of Hematology,Faculty of Paramedicine,Bushehr University of Medical Sciences,Bushehr 75146-33341,Iran

出　　处：《Acta Oceanologica Sinica》2022年第12期133-141,共9页海洋学报（英文版）

基　　金：The Iran National Science Foundation under contract No. 96015033

摘　　要：Marine macroalgal sulfated fucose-containing polysaccharides,like fucoidan,have drawn significant attention due to their biotechnological potentials,such as anti-cancer,antioxidant,and anti-cholinesterase activities.The fucoidan derived from brown macroalgae Sargassum angustifolium species(FSA)was investigated for its cytotoxic effects and alterations in cell proliferation,and cell cycle-related gene expression in the present study occurred on NB4 cell line.The results showed that FSA would induce p53,p21,pro-apoptotic genes and increase expression of the p15 gene as a cell arrest marker.Also,FSA inhibited the anti-apoptotic effect of the Bcl-2 gene and decreased dnmt-1 gene expression.FSA significantly exhibited potent 2,2-diphenyl-1-picrylhydrazyl(DPPH)radical scavenging activity(p<0.05)with an IC_(50) value of 0.157 mg/mL and showed moderate anti-acetylcholinesterase activity with an IC_(50) value of 1.20μg/mL.These results indicated the potential of FSA for the development of therapeutic or preventive agents of cancer and Alzheimer’s disease mainly through cytotoxic effect and AChE(acetylcholinesterase)inhibition as well as additional antioxidant capacities.

关 键 词：FUCOIDAN Sargassum angustifolium CYTOTOXICITY ANTIOXIDANT anti-cholinesterase 

分 类 号：Q943[生物学—植物学] P73[天文地球—海洋科学]