887例儿童内分泌器官实体肿瘤的临床病理特征分析  

Pathological characteristics of solid tumors of endocrine organs in 887 children

作　　者：王冰 何林 顾伟忠[2] 黄轲[1] 吴蔚[1] 袁金娜[1] 傅君芬[1] 董关萍[1] Wang Bing;He Lin;Gu Weizhong;Huang Ke;Wu Wei;Yuan Jinna;Fu Junfen;Dong Guanping(Department of Endocrinology,Children's Hospital,Zhejiang University School of Medicine,Hangzhou 310051,China;Department of Pathology,Children's Hospital,Zhejiang University School of Medicine,Hangzhou 310051,China)

机构地区：[1]浙江大学医学院附属儿童医院内分泌科,浙江杭州310051 [2]浙江大学医学院附属儿童医院病理科,浙江杭州310051

出　　处：《实用肿瘤杂志》2023年第1期38-45,共8页Journal of Practical Oncology

基　　金：浙江省肿瘤智能诊断与分子技术研究中心(JBZX-202003)。

摘　　要：目的探讨儿童内分泌器官实体肿瘤的临床病理特征。方法选取2014年1月至2020年12月浙江大学医学院附属儿童医院就诊的、经病理诊断为内分泌器官肿瘤患儿作为研究对象。分析儿童内分泌器官实体肿瘤的性别、年龄、良恶性和临床病理类型的分布情况以及随时间变化的趋势。结果共纳入887例内分泌器官肿瘤患儿。其中,男性322例,女性565例;平均年龄为6.11岁;良性肿瘤503例(56.71%),恶性肿瘤384例(43.29%)。男性患儿内分泌器官肿瘤主要发生于睾丸,最常见的病理类型是青春期前型畸胎瘤,而女性则是卵巢部位的成熟畸胎瘤。恶性内分泌器官肿瘤见于各年龄段,婴幼儿期患儿恶性肿瘤占比最高(62.31%),其次是学龄前期(53.54%)和学龄期(27.49%),差异具有统计学意义(χ^(2)=93.051,P<0.01)。不同年龄段睾丸肿瘤患儿中恶性占比从高到低依次为青春期(66.67%)、婴幼儿期(41.53%)、学龄前期(21.43%)和学龄期(12.50%),差异具有统计学意义(χ^(2)=11.452,P=0.006)。不同年龄段的胰腺、卵巢和睾丸肿瘤患儿的主要病理类型分布情况比较,差异均具有统计学意义(均P<0.05)。随着时间变化,儿童内分泌器官实体肿瘤的数量呈上升趋势,其中卵巢(χ^(2)=9.792)和肾上腺(χ^(2)=19.022)部位的肿瘤恶性占比升高差异均具有统计学意义(均P<0.05)。结论儿童内分泌器官肿瘤良恶性比例相近,不同年龄和性别的内分泌肿瘤发生部位及病理类型分布各异。儿童内分泌肿瘤发病数量及部分恶性肿瘤占比呈增多趋势,建议结合流行特点制定针对性的防治方案。Objective To investigate the pathological characteristics of solid tumors of endocrine organs in children.Methods Children pathologically diagnosed as endocrine organ tumors in the Children’s Hospital,Zhejiang University School of Medicine from January 2014to December 2020 were selected as subjects.The distribution of sex,age,benign/malignant,and clinicopathological types of solid tumors of endocrine organs in children were analyzed,as well as the trend of changes over time.Results A total of 887 children with endocrine organ tumors were included.Of these,322 were male and 565 were female;the mean age was 6.11 years;there were 503 benign tumors(56.71%)and 384 malignant tumors(43.29%).In males,the endocrine organ tumors occurred mainly in the testis and the most common pathological type was prepubertal teratoma,while in females it was mature teratoma in the ovarian area.Malignant endocrine organ tumors were seen in all age groups,with the highest proportion of malignant tumors in infants(62.31%),followed by preschool(53.54%)and school age(27.49%),with a statistically significant difference(χ^(2)=93.051,P<0.01).The proportion of malignant tumors in children with testicular tumors in the different age groups was 66.67%in adolescence,41.53%in infants,21.43%in preschool and 12.50%in school age,with statistically significant difference(χ^(2)=11.452,P=0.006).There were statistically significant differences in the distribution of the main pathological types of pancreatic,ovarian and testicular tumors in children at different ages(all P<0.05).The number of solid tumors of endocrine organs in children tended to increase over time,with a statistically significant difference in the proportion of tumors with increased malignancy in ovary(χ^(2)=9.792)and adrenal(χ^(2)=19.022)sites(both P<0.05).Conclusions The proportion of benign and malignant endocrine organ tumors in children is similar,and the distribution of sites and pathological types of endocrine tumors vary by age and sex.The number of endocrine tumors and the pr

关 键 词：内分泌器官肿瘤 病理特征 儿童 

分 类 号：R736[医药卫生—肿瘤]