查尔酮类化合物抗肿瘤活性研究进展  

Research Progress on Anti-tumor Activity of Chalcone Derivatives

作　　者：李林博 刘玉肖 樊平平 周淑晶[1,2] 李进京 LI Lin-bo;LIU Yu-xiao;FAN Ping-ping;ZHOU Shu-jing;LI Jin-jing(College of Pharmacy,Jiamusi University,Jiamusi 154007,China;Heilongjiang Institute of Pharmacy,Jiamusi 154007,China)

机构地区：[1]佳木斯大学药学院,黑龙江佳木斯154007 [2]黑龙江省药学研究所,黑龙江佳木斯154007

出　　处：《化学试剂》2023年第2期33-42,共10页Chemical Reagents

基　　金：黑龙江省属高校基本科研业务费项目(2018-KYYWF-0946);佳木斯大学博士启动项目(JMSUZB2018-02)。

摘　　要：天然产物查尔酮因其具有广泛的生物活性而被人们所关注。特别是在抗肿瘤方面,可作用于多种抗癌靶标从而发挥抗肿瘤作用,如EGFR、VEGFR-2、Ntoch信号通路、PI3K/AKT信号通路、WNT/β-cantenin信号通路以及线粒体介导的细胞凋亡信号通路等。依据不同抗癌机制对近年来查尔酮及其衍生物在抗肿瘤活性方面的研究成果进行分类阐述,为新型含α,β-不饱和酮结构的抗肿瘤药物的研发工作提供参考。Chalcone as the natural product has attracted people′s attention due to its diverse biological activities.Especially in terms of anti-tumor effect,it can bind to a variety of anti-cancer targets,such as EGFR,VEGFR-2,Ntoch signaling pathway,PI3K/AKT signaling pathway,WNT/β-cantenin signaling pathway and mitochondrial-mediated apoptosis signaling pathway.Classified by anti-cancer mechanism,the account was mainly focused on the research of chalcone derivatives in anti-tumor field in the last years,in order to provide references in the development of novel anti-tumor drugs containingα,β-unsaturated ketone structure.

关 键 词：查尔酮 天然产物 抗癌靶标 抗肿瘤活性 研究进展 

分 类 号：R979.1[医药卫生—药品]