Roles of eIF5A in the immunosurveillance of cellular senescence  

作　　者：Xiangli Jiang Fabricio Loayza-Puch 

机构地区：[1]Department of Thoracic Oncology,Tianjin Medical University Cancer Institute&Hospital,National Clinical Research Center for Cancer,Key Laboratory of Cancer Prevention and Therapy,Tianjin,Tianjin's Clinical Research Center for Cancer,Tianjin 300060,China [2]Translational Control and Metabolism,German Cancer Research Center(DKFZ),Heidelberg 69120,Germany

出　　处：《Cancer Biology & Medicine》2022年第11期1523-1527,共5页癌症生物学与医学（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China (Grant No. 81501988);the DKFZ Clinician Scientist Program,which is sponsored by the Dieter Morszeck Foundation

摘　　要：Senescence is a cellular stress response program that prevents the proliferation of oncogenically activated, genetically unstable, and/or damaged cells. Senescence was first described in 1961, when normal cultured human fibroblasts were found to enter irreversible growth arrest after multiple cell divisions, in a process known as replicative senescence1. Several types of senescence have since been identified, such as stress-induced senescence, oncogene-induced senescence, and virus-induced senescence. Despite having distinct features due to their different triggers, senescent cells share several key features.

关 键 词：UNSTABLE SASP SENESCENCE 

分 类 号：R363[医药卫生—病理学]