Hypothalamic GABAergic neurocircuitry in the regulation of energy homeostasis and sleep/wake control  

作　　者：Hong Jiang 

机构地区：[1]Department of Neurobiology,School of Basic Medical Sciences,Neuroscience Research Institute,Peking University,No.38,Xueyuan Road,Haidian District,Beijing 100083,China [2]Key Laboratory for Neuroscience,Ministry of Education/National Health Commission of China,Peking University,Beijing 100083,China

出　　处：《Medical Review》2022年第5期531-540,共10页医学评论（英文）

基　　金：supported by“the Fundamental Research Funds for the Central Universities”Starting fund(grant 71013Y2156)to Hong Jiang.

摘　　要：Gamma-aminobutyric acid(GABAergic)neuron,as one of important cell types in synaptic transmission,has been widely involved in central nervous system(CNS)regulation of organismal physiologies including cognition,emotion,arousal and reward.However,upon their distribution in various brain regions,effects of GABAergic neurons in the brain are very diverse.In current report,we will present an overview of the role of GABAergic mediated inhibitory neurocircuitry in the hypothalamus,underlying mechanism of feeding and sleep homeostasis as well as the characteristics of latest transcriptome profile in order to call attention to the GABAergic system as potentially a promising pharmaceutical intervention or a deep brain stimulation target in eating and sleep disorders.

关 键 词：energy homeostasis feeding gamma-aminobutyric acid HYPOTHALAMUS NEUROCIRCUITRY SLEEP wakefulness. 

分 类 号：R74[医药卫生—神经病学与精神病学]