葡萄糖-6-磷酸脱氢酶缺乏症溶血风险相关物质的研究进展  

Research progress in substances related to hemolysis risk in glucose-6-phosphate dehydrogenase deficiency

作　　者：李津婴 宋洪杰 李津杞 顾海慧 钱宝华 LI Jinying;SONG Hongjie;LI Jinqi;GU Haihui;QIAN Baohua(Department of Transfusion Medicine,Shanghai 200433,China;PLA Research&Innovation Base of Pediatric Hemolytic Anemia,Shanghai 200433,China;Department of Pharmacy,the First Affiliated Hospital of Naval Medical University,Shanghai 200433,China)

机构地区：[1]海军军医大学第一附属医院输血科,上海200433 [2]全军儿童溶血性贫血研究创新基地,上海200433 [3]海军军医大学第一附属医院药剂科,上海200433

出　　处：《中国药物警戒》2023年第1期110-116,共7页Chinese Journal of Pharmacovigilance

基　　金：国家自然科学基金资助项目(81970165);医院“234学科攀峰计划”(2020YXK036)。

摘　　要：药物性溶血是葡萄糖-6-磷酸脱氢酶缺乏症(G6PDd)发生急性溶血的常见诱因之一,随着新药研发和面市,涉及G6PDd溶血的药物逐年增加。本文分类介绍对G6PDd有溶血风险的抗生素、抗病毒、抗肿瘤药物,解热镇痛消炎药,代谢类药物,扩血管药物,麻醉剂,解毒剂,其他药物,中草药、植物,外用药、试剂、化学品及食品,为临床医生治疗选择和病患警示预防提供参考。Drug-induced hemolysis is one of the common causes of acute hemolysis in glucose-6-phosphate dehydrogenase deficiency(G6PDd).With the development and marketing of new drugs,cases of drug-induced hemolysis in G6PDd are increasing year by year.This paper lists and updates antibiotics,antivirals,antineoplastics,antipyretics,anti-inflammatory drugs,metabolic drugs,vasodilators,anaesthetics,antidotes,other drugs,herbs,plants,topical drugs,reagents,chemicals and food with hemolysis risk for G6PDd so as to facilitate clinical selection of treatments and warning and prevention of this disease.

关 键 词：葡萄糖-6-磷酸脱氢酶缺乏症 溶血风险 高铁血红蛋白血症 药物 化学品 食物 

分 类 号：R994.11[医药卫生—毒理学]