TNF-α,IL-6 and hs CRP in patients with melancholic,atypical and anxious depression:an antibodyyarrayanalysis related to somatic symptoms  

作　　者：Hongmei Liu Xiaohui Wu Yun Wang Xiaohua Liu Daihui Peng Yan Wu Jun Chen Yun-Ai Su Jia Xu Xiancang Ma Yi Li Jianfei Shi Xiaodong Yang Han Rong Marta Di Forti Yiru Fang 

机构地区：[1]Clinical Research Center,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai,China [2]Shanghai Key Laboratory of Psychotic Disorders,Shanghai,China [3]Peking University Sixth Hospital,Beijing,China [4]Harbin First Specific Hospital,Harbin,China [5]Department of Psychiatry,The First Affiliated Hospital of Xi'an Jiaotong University,Xian,China [6]Wuhan Mental Health Center,Wuhan,China [7]Hangzhou Seventh People's Hospital,Hangzhou,China [8]Shandong Mental Health Center,Jinan,China [9]Shenzhen Mental Health Center,Shenzhen,China [10]Department of Social Genetics and Developmental Psychiatry Institute of Psychiatry Psychology and Neuroscience,King's College London,London,UK [11]Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence,Guangzhou,China [12]State Key Laboratory of Neuroscience,Shangha nstitute for Biological Sciences,CAS,Shanghai,China

出　　处：《General Psychiatry》2022年第5期354-365,共12页综合精神医学（英文）

基　　金：Key Projects of Clinical Research Center of Shanghai Mental Health Center(grant number CRC2018ZD02);key supporting projects of Clinical Research Center of Shanghai Mental Health Center(grant number SHDC 2020CR6023);Research and DevelopmentProgramof China(grant number 2016YFC1307100);Shanghai Key Project of Science and Technology(grant number 2018SHZDZX05);Natural Science Foundation of China(grant number 81771465,81801338 and 81930033).

摘　　要：Background The association between inflammation and major depressive disorder(MDD)remains poorly understood,given the heterogeneity of patients with MDD.Aims We investigated inflammatory markers,such as interleukin(IL)-6,high-sensitivity C reactive protein(hsCRP)and tumour necrosis factor-α.(TNF-α)in melancholic,atypical and anxious depression and explored whether baseline inflammatory protein levels could indicate prognosis.Methods The sample consisted of participants(aged 18-55 years)from a previously reported multicentre randomised controlled trial with a parallel-group design registered with ClinicalTrials.gov,including melancholic(n=44),atypical(n=37)and anxious(n=44)patients with depression and healthy controls(HCs)(n=33).Subtypes of MDD were classified according to the 30-item Inventory of Depressive Symptomatology,Self-Rated Version and the.17-item Hamilton Depression Rating Scale.Blood levels.of TNF-α,IL-6 and hsCRP were assessed using antibody array analysis.Results Patients with MDD,classified according to melancholic,atypical and anxious depression subtypes,and HCs did not differ significantly in baseline TNF-α,IL-6 and hsCRP levels after adjustment.In patients with anxious depression,hsCRP levels increased significantly if they experienced no pain(adjusted(adj.)p=0.010)or mild to moderate pain(adj.p=0.038)compared with those with severe pain.However,the patients with anxious depression and severe pain showed a lower trend in hsCRP levels than patients with atypical depression who experienced severe pain(p=0.022;adj.p=0.155).Baseline TNF-α(adj.p=0.038)and IL-6(adj.p=0.006)levels in patients in remission were significantly lower than those in patients with no remission among the participants with the atypical depression subtype at the eighth-week follow-up.Conclusions This study provides evidence of differences in inflammatory proteins in patients with varied symptoms among melancholic,atypical and anxious depression subtypes.Further studies on the immunoinflammatory mechanism underlying different

关 键 词：PATIENTS ATYPICAL BLOOD 

分 类 号：R749[医药卫生—神经病学与精神病学]