蜂蜜中抗菌活性物质及其抑菌作用机理研究进展  

Research Progress of the Antibacterial Active Substances from Honey and Their Antibacterial Mechanisms

作　　者：袁文芹 玄红专[1] 王凯[2] YUAN Wenqin;XUAN Hongzhuan;WANG Kai(School of Life Science,Liaocheng University,Liaocheng 252059,China;Institute of Apicultural Research,Chinese Academy of Agricultural Sciences,Beijing 100093,China)

机构地区：[1]聊城大学生命科学学院,山东聊城252059 [2]中国农业科学院蜜蜂研究所,北京100093

出　　处：《食品工业科技》2023年第4期438-446,共9页Science and Technology of Food Industry

基　　金：国家自然科学基金面上项目(32172791);中央级公益性科研院所基本科研业务费专项(MFSJKF2021-06);山东省蜂产业技术体系蜂产品加工与质量控制岗位(SDAIT-24-05)。

摘　　要：蜂蜜是由工蜂采集的花蜜及其自身分泌物混合而成的一种天然甜味物质,具有良好的抗菌活性,含有多种天然抗菌活性物质。近年来,已有大量研究报道了蜂蜜中抗菌活性物质的研究进展,包括甲基乙二醛、过氧化氢、多酚、抗菌肽和王浆主蛋白等。大量研究表明,过氧化氢是蜂蜜中最重要的抗菌活性物质之一。本文着重综述了各抗菌有效活性物质在蜂蜜抑菌过程中所发挥的重要作用,进一步以蜂蜜中的过氧化氢为例,总结了葡萄糖氧化酶催化葡萄糖生成过氧化氢的过程,并对产生和降解过氧化氢的其他途径以及影响过氧化氢产生的理化因素进行了综述。合理调控蜂蜜中过氧化氢的产生,对蜂蜜抑菌乃至其他生物活性发挥起着重要的作用。本综述也为蜂蜜的临床安全用药及相关功能食品研发提供参考依据。Honey is a natural sweet substance made from a mixture of nectar collected by worker bees and their own secretions,which has good antibacterial activity and contains a variety of natural antibacterial active substances.In recent years,a large number of studies have been reported on the progress of antimicrobial active substances in honey,including methylglyoxal,hydrogen peroxide,polyphenols,antimicrobial peptides and Major royal jelly proteins.Numerous studies have shown that hydrogen peroxide is one of the most important antibacterial substances in honey.This paper highlights the important roles by each antimicrobial effective active substance for the anti-bacterial by honey.It also further summarizes the process of glucose oxidase catalyzing the production of hydrogen peroxide from glucose.The process of glucose oxidase catalyzing the production of hydrogen peroxide from glucose is summarized using hydrogen peroxide in honey as an example.Other pathways for the production and degradation of hydrogen peroxide and the physicochemical factors affecting the production of hydrogen peroxide are also reviewed.Rational regulation of hydrogen peroxide production in honey plays an important role in its antibacterial and even other biological activities.This review would also provide a reference for the safe clinical use of honey and the development of functional foods.

关 键 词：蜂蜜 抗菌活性 葡萄糖氧化酶 过氧化氢 胶体结构 

分 类 号：S896.1[农业科学—特种经济动物饲养]