Unraveling the Emerging Niche Role of Hepatic Stellate Cell-derived Exosomes in Liver Diseases  

作　　者：Kun-Li Yin Ming Li Pei-Pei Song Yu-Xin Duan Wen-Tao Ye Wei Tang Norihiro Kokudo Qiang Gao Rui Liao 

机构地区：[1]Department of Hepatobiliary Surgery,the First Affiliated Hospital of Chongqing Medical University,Chongqing,China [2]National Center for Global Health and Medicine,Tokyo,Japan [3]Department of Liver Surgery and Transplantation,and Key Laboratory of Carcinogenesis and Cancer Invasion(Ministry of Education),Liver Cancer Institute,Zhongshan Hospital,Fudan University,Shanghai,China [4]Key Laboratory of Medical Epigenetics and Metabolism,Institutes of Biomedical Sciences,Fudan University,Shanghai,China [5]State Key Laboratory of Genetic Engineering,Fudan University,Shanghai,China

出　　处：《Journal of Clinical and Translational Hepatology》2023年第2期441-451,共11页临床与转化肝病杂志（英文版）

基　　金：supported by Japanese China Sasakawa Medical Fellowship,Science and Health Joint Research Project of Chongqing Municipality (2020GDRC013);Program for Youth Innovation in Future Medicine,Chongqing Medical University (W0087).

摘　　要：Hepatic stellate cells(HSCs)play an essential role in various liver diseases,and exosomes are critical mediators of intercellular communication in local and distant microenvironments.Cellular crosstalk between HSCs and surrounding multiple tissue-resident cells promotes or inhibits the activation of HSCs.Substantial evidence has revealed that HSC-derived exosomes are involved in the occurrence and development of liver diseases through the regulation of retinoid metabolism,lipid metabolism,glucose metabolism,protein metabolism,and mitochondrial metabolism.HSCderived exosomes are underpinned by vehicle molecules,such as mRNAs and microRNAs,that function in,and significantly affect,the processes of various liver diseases,such as acute liver injury,alcoholic liver disease,nonalcoholic fatty liver disease,viral hepatitis,fibrosis,and cancer.As such,numerous exosomes derived from HSCs or HSCassociated exosomes have attracted attention because of their biological roles and translational applications as potential targets for therapeutic targets.Herein,we review the pathophysiological and metabolic processes associated with HSC-derived exosomes,their roles in various liver diseases and their potential clinical application.

关 键 词：MYOFIBROBLAST Extracellular vesicle Hepatic fibrosis Cancer Metabolic reprogramming Biomarker 

分 类 号：R575[医药卫生—消化系统]