MYOFIBROBLAST

作品数：62被引量：340H指数：10
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相关领域：医药卫生更多>>
相关作者：王华张浩军赵婷婷李平李庆云更多>>
相关机构：上海交通大学中国医学科学院北京协和医学院中日友好医院第四军医大学口腔医院更多>>
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Subretinal fibrosis secondary to neovascular age-related macular degeneration:mechanisms and potential therapeutic targets
《Neural Regeneration Research》2025年第2期378-393,共16页Jingxiang Zhang Xia Sheng Quanju Ding Yujun Wang Jiwei Zhao Jingfa Zhang 
supported by grants from National Key R&D Program of China,No.2023YFC2506100(to JZ);the National Natural Science Foundation of China,No.82171062(to JZ).
Subretinal fibrosis is the end-stage sequelae of neovascular age-related macular degeneration.It causes local damage to photoreceptors,retinal pigment epithelium,and choroidal vessels,which leads to permanent central ...
关键词：choroidal neovascularization epithelial-mesenchymal transition mesenchymal transition MYOFIBROBLAST neovascular age-related macular degeneration submacular fibrosis subretinal fibrosis therapeutic targets transforming growth factor-β vascular endothelial growth factor 
Effect of macrophage- to- myofibroblast transition on silicosis
《Animal Models and Experimental Medicine》2025年第2期363-371,共9页Fei Geng Jingrou Xu Xichen Ren Ying Zhao Yuhao Cai Yaqian Li Fuyu Jin Tian Li Xuemin Gao Wenchen Cai Hong Xu Zhongqiu Wei Na Mao Ying Sun Fang Yang 
The National Natural Science Foundation of China(no.82204006);the Science and Technology of Project of Hebei Education Department(QN2022009);the Provincial Graduate Student Innovation Funding Project of Hebei Province(CXZZBS2022104);the National Natural Science Foundation of Hebei Province(H2020209292).
Background:The aim was to explore the effect of macrophage polarization and macrophage-to-myofibroblast transition(MMT)in silicosis.Methods:Male Wistar rats were divided into a control group and a silicosis group deve...
关键词：MACROPHAGE macrophage-to-myofibroblast transition SILICOSIS 
Understanding myofibroblast origin in the fibrotic lung
《Chinese Medical Journal Pulmonary and Critical Care Medicine》2024年第3期142-150,共9页Mahsa Zabihi Mahtab Shahriari Felordi Arun Lingampally Saverio Bellusci Xuran Chu Elie El Agha 
B was supported by grants from the German Research Foundation(DFG;Nos.BE 4443/1-1,BE 4443/4-1,BE4443/6-1,KFO309284237345 P7 and CRC1213268555672 projects A02 and A04);German Center for Lung Research(DZL),and Excellence Cluster CardioPulmonary Institute(CPI;No.EXC2026390649896);XC acknowledges the support of the Natural Science Foundation of Zhejiang Grant(No.LQ24H210001);EEA was supported by the DFG(Nos.EL 931/5-1,EL 931/4-1,KFO309284237345 P7 and SFB CRC1213268555672 project A04),Institute for Lung Health(ILH),CPI,and DZL.
Idiopathic pulmonary fibrosis(IPF)is characterized by accumulation of myofibroblasts(MYFs)and extracellular matrix components,which leads to severe distortion and scarring of the gas exchange units of the lung,the alv...
关键词：Idiopathic pulmonary fibrosis MYOFIBROBLASTS Fibrotic disease Myofibroblast heterogeneity Lineage tracing 
Topographical cues of biomaterials and fibroblast activation:Are they related?
《Mechanobiology in Medicine》2024年第1期7-9,共3页Zuhan Chen Huanjing Bi Xiaoming Ding 
supported by the National Science Foundation of China(82370802);Xi'an Jiaotong University Medical Basics-Clinical Integration Innovation Project(YXJLRH2022049).
The implantation of foreign materials often leads to fibroblast activation and fibrous capsule formation.The process of fibroblast-to-myofibroblast transition(FMT)is partially influenced by the surface properties of b...
关键词：Biomaterial FIBROBLAST Topography MYOFIBROBLAST MECHANOBIOLOGY 
Cytokine receptor-like factor 1(CRLF1)promotes cardiac fibrosis via ERK1/2 signaling pathway
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2023年第8期682-697,共16页Shenjian LUO Zhi YANG Ruxin CHEN Danming YOU Fei TENG Youwen YUAN Wenhui LIU Jin LI Huijie ZHANG 
supported by the National Key Research and Development Project of China(No.2018YFA0800404);the National Natural Science Foundation of China(Nos.82100255 and 81970736);the China Postdoctoral Science Foundation(Nos.2021M691459 and 2022T150299).
Cardiac fibrosis is a cause of morbidity and mortality in people with heart disease.Anti-fibrosis treatment is a significant therapy for heart disease,but there is still no thorough understanding of fibrotic mechanism...
关键词：Cytokine receptor-like factor 1(CRLF1) TGF-β1/SMAD signaling pathway ERK1/2 signaling pathway Cardiac fibrosis Myofibroblast transformation Extracellular matrix(ECM) 
Myofibroblast宜译为“肌性成纤维细胞”而不是“肌成纤维细胞”被引量：1
《中国医学前沿杂志（电子版）》2023年第7期81-81,共1页戴生明 
成纤维细胞(fibroblast)是一种间充质细胞,是结缔组织中最常见的细胞成分,可合成细胞外基质成分,对于维持组织内稳态至关重要。正常情况下它们不表达α平滑肌肌动蛋白(α smooth muscle actin,α-SMA)。以皮肤真皮层中的成纤维细胞最为...
关键词：Α平滑肌肌动蛋白 细胞外基质成分 成纤维细胞 真皮层 间充质细胞 内稳态 Myo 
Unraveling the Emerging Niche Role of Hepatic Stellate Cell-derived Exosomes in Liver Diseases被引量：1
《Journal of Clinical and Translational Hepatology》2023年第2期441-451,共11页Kun-Li Yin Ming Li Pei-Pei Song Yu-Xin Duan Wen-Tao Ye Wei Tang Norihiro Kokudo Qiang Gao Rui Liao 
supported by Japanese China Sasakawa Medical Fellowship,Science and Health Joint Research Project of Chongqing Municipality (2020GDRC013);Program for Youth Innovation in Future Medicine,Chongqing Medical University (W0087).
Hepatic stellate cells(HSCs)play an essential role in various liver diseases,and exosomes are critical mediators of intercellular communication in local and distant microenvironments.Cellular crosstalk between HSCs an...
关键词：MYOFIBROBLAST Extracellular vesicle Hepatic fibrosis Cancer Metabolic reprogramming Biomarker 
Huoxue Jiedu Huayu recipe(活血解毒化瘀方)alleviates contralateral renal fibrosis in unilateral ureteral obstruction rats by inhibiting the transformation of macrophages to myofibroblast被引量：2
《Journal of Traditional Chinese Medicine》2023年第1期105-112,共8页XIONG Yunzhao LIU Lingjin LIU Ziqian CHEN Gege HAO Juan GAO Xiaomeng QIANG Panpan WANG Zheng XU Qingyou 
Supported by Natural Science Foundation-funded Project:Effect of Macrophage-to-Myofibroblast Transition in Contralateral Kidney of Unilateral Ureteral Obstruction Rats Through the Aldosterone/MR/SGK1 Pathway and Inhibition of Chinese Herbs(No.81873251);Natural Science Foundation-funded Project:Aldosterone-induced Macrophage Polarization-lymphatic Endothelial Cell-like Transformation Involved in Renal Fibrosis and the Protective Effect of Yiqi Jiedu Huayu Herbs(No.82205006);Youth Top Talent Project of Hebei Provincial Department of Education:Mechanism of Renal Fibrosis Induced by NF-kB/IL-8 Induced MMT in UUO Rats(BJK2022004)。
OBJECTIVE:To investigate the action and underlying mechanisms of Huoxue Jiedu Huayu recipe(活血解毒化瘀方,HJHR)against unilateral ureteral obstruction(UUO)-induced injury in the contralateral kidney.METHODS:Forty-eigh...
关键词：ureteral obstruction renal fibrosis ALDOSTERONE receptors mineralocorticoid MACROPHAGES MYOFIBROBLAST Huoxue Jiedu Huayu recipe 
Single-cell analysis reveals that cancer-associated fibroblasts stimulate oral squamous cell carcinoma invasion via the TGF-β/Smad pathway被引量：2
《Acta Biochimica et Biophysica Sinica》2023年第2期262-273,共12页Wenbin Yang Shunhao Zhang Tianle Li Zirui Zhou Jian Pan 
This work was supported by the grants from the Research and Develop Program,West China Hospital of Stomatology Sichuan University(No.LCYJ2019-1 to J.P.);the Interdisciplinary and Intercollege Research Project of the State Key Laboratory of Sichuan University(No.2021KXK0403 to J.P.);the Sichuan University-Panzhihua City 2021 Campus Cooperation Special Fund Project(No.2021CDPZH-7 to W.Y.);the College Students’Innovative Entrepreneurial Training Plan Program(No.202210610194 to S.Z.).
Although substantial progress has been made in cancer biology and treatment,the prognosis of oral squamous cell carcinoma(OSCC)is still not satisfactory because of local tumor invasion and frequent lymph node metastas...
关键词：oral squamous cell carcinoma cancer-associated fibroblast MYOFIBROBLAST TGF-Β single cell 
Intrarenal 1-methoxypyrene,an aryl hydrocarbon receptor agonist,mediates progressive tubulointerstitial fibrosis in mice被引量：4
《Acta Pharmacologica Sinica》2022年第11期2929-2945,共17页Gang Cao Hua Miao Yan-ni Wang Dan-qian Chen Xia-qing Wu Lin Chen Yan Guo Liang Zou Nosratola D.Vaziri Ping Li Ying-yong Zhao 
the National Natural Science Foundation of China(Nos.82074002,81922073,81872985);the National Key Research and Development Project of China(No.2019YFC1709405).
Recent studies have shown that endogenous metabolites act via aryl hydrocarbon receptor(AhR)signalling pathway in tubulointerstitial fibrosis(TIF)pathogenesis.However,the mechanisms underlying endogenous metabolite-me...
关键词：tubulointerstitial fibrosis aryl hydrocarbon receptor epithelial-mesenchymal transition macrophage-myofibroblast transition metabolomics Semen plantaginis 
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