Fuzheng Huayu Capsule Improves Survival in Patients with HepatitisB-related Cirrhosis and Overt Hepatic Encephalopathy  

作　　者：Ke Shi Yi Zhang Yufei Bi Xuanwei Zeng Xianbo Wang 

机构地区：[1]Center of integrative medicine,Beijing Ditan Hospital,Capital Medical University,Beijing,100015,China

出　　处：《Journal of Integrative Medicine（双语）》2022年第2期29-37,共9页中西医结合杂志（英文）

基　　金：supported by the Beijing Municipal Science and Technology Commission,NO.Z191100006619033.

摘　　要：Objective:Fuzheng Huayu(FZHY)capsules exert anti-liver fibrosis and cirrhosis effects.This study aimed to determine the effect of FZHY on the 6-month survival rate of patients with overt hepatic encephalopathy(OHE)and hepatitis B-related cirrhosis(HBC).Methods:A total of 517 patients with OHE and HBC treated between January 2008 and July 2018 were enrolled.Patients were divided into the FZHY(n=129)and control groups(n=388),and the 6-month survival rates were compared between the two groups.Propensity score matching(PSM)was used to reduce the bias caused by confounding factors.Results:In multivariable regression analysis,FZHY therapy was an independent protective factor of 6-month survival.After PSM(1:2),the FZHY and control group comprised 126 and 252 patients,respectively.The 6-month survival rate was remarkably higher in the FZHY group than in the control group(P<0.005).FZHY users,especially those with a model for end-stage liver disease score>20 and Child-Pugh class C,benefited significantly from FZHY therapy.Conclusions:Adjuvant therapy with FZHY may be associated with improved survival in patients with OHE and HBC.However,further clinical studies are required to validate our findings.

关 键 词：Traditional Chinese medicine Fuzheng Huayu capsule CIRRHOSIS Hepatic encephalopathy PROGNOSIS 

分 类 号：R57[医药卫生—消化系统]