神经毒素BMAA的生物合成、食物链传递及其致病机理的研究进展与展望  

Progress and Prospect of the Biosynthesis,Food Chain Transfer and Pathogenic Mechanisms for Neurotoxin BMAA

作　　者：李爱峰[1,2] 闫业举 邱江兵 李敏 付艺蕾 Li Aifeng;Yan Yeju;Qiu Jiangbing;Li Min;Fu Yilei(College of Environmental Science and Engineering,Ocean University of China,Qingdao 266100,China;The Key Laboratory of Marine Environment and Ecology,Ministry of Education,Ocean University of China,Qingdao 266100,China)

机构地区：[1]中国海洋大学环境科学与工程学院,山东青岛266100 [2]中国海洋大学海洋环境与生态教育部重点实验室,山东青岛266100

出　　处：《中国海洋大学学报（自然科学版）》2023年第2期10-21,共12页Periodical of Ocean University of China

基　　金：国家自然科学基金山东联合基金重点支持项目(U2106205);国家自然科学基金项目(41676093)资助。

摘　　要：本文参考有关BMAA的来源、作用机制及可能的生物合成过程等方面的研究论文,系统介绍了最早在苏铁组织中发现的BMAA毒素在淡水或海洋环境中蓝细菌、硅藻和甲藻样品中的检出情况及其沿食物链的生物放大作用,梳理了BMAA的毒性机制及可能的生物合成途径,并客观分析了BMAA诱发人神经退行性疾病的假说。最后,对BMAA未来的研究方向进行了展望。The neurotoxin BMAA,β-N-methylamino-l-alanine,is one of derivatives of amino acid,which has been deemed to be linked with some neurodegenerative diseases distributed widely in the world,such as Amyotrophic Lateral Sclerosis-Parkinsonism Dementia Complex(ALS-PDC)and Alzheimer’s Disease(AD).Based on review for a lot of papers on the source,toxicological mechanisms and possible biosynthesis process of BMAA,this paper comprehensively introduces the detection of BMAA found firstly in cycad tissues in samples of cyanobacteria,diatoms,and dinoflagellates in freshwater or seawater environments and its biomagnification along food chains,sorts out the toxicity and possible biosynthesis mechanisms of BMAA,and critically analyzes the hypothesis for BMAA inducing the neurodegenerative diseases in humans.Finally,the future research directions of BMAA are prospected.

关 键 词：BMAA 来源 生物合成 生物放大 致病机理 

分 类 号：X131[环境科学与工程—环境科学]