Effects of Norepinephrine on Renal Cortical and Medullary Blood Flow in Atherosclerotic Rabbits  

作　　者：Jia-yu WANG Jie SUN You-bin DENG Yu-bo WANG Kun LIU 

机构地区：[1]Department of Medical Ultrasound,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430030,China [2]Department of Medical Ultrasound,Maternal and Child Healthcare Hospital of Hubei Province,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430064,China [3]Department of Medical Ultrasound,The Third People’s Hospital of Hubei Province,Wuhan,430030,China

出　　处：《Current Medical Science》2022年第6期1172-1177,共6页当代医学科学（英文）

基　　金：supported by grants from Health and Family Planning Commission Foundation of Hubei Province(No.WJ2017M080);the National Natural Science Foundation of China(No.81601507).

摘　　要：Objective The aim of this study was to explore the effect of norepinephrine(NE)on renal cortical and medullary blood flow in atherosclerotic rabbits without renal artery stenosis.Methods Atherosclerosis was induced in 21 New Zealand white rabbits by feeding them a cholesterol-rich diet for 16 weeks.Thirteen healthy New Zealand white rabbits were randomly selected as controls.After atherosclerosis induction,standard ultrasonography was performed to confirm that there was no plaque or accelerated flow at the origin of the renal artery.Contrast-enhanced ultrasound(CEUS)was performed at baseline and during intravenous injection of NE.The degree of contrast enhancement of renal cortex and medulla after the injection of contrast agents was quantified by calculating the enhanced intensity.Results The serum nitric oxide(NO)level in atherosclerotic rabbits was higher than that in healthy rabbits(299.6±152 vs.136.5±49.5,P<0.001).The infusion of NE induced a significant increase in the systolic blood pressure(112±14 mmHg vs.84±9 mmHg,P=0.016)and a significant decrease in the enhanced intensity in renal cortex(17.78±2.07 dB vs.21.19±2.03 dB,P<0.001)and renal medulla(14.87±1.82 dB vs.17.14±1.89 dB,P<0.001)during CEUS.However,the enhanced intensity in the cortex and medulla of healthy rabbits after NE infusion showed no significant difference from that at baseline.Conclusion NE may reduce renal cortical and medullary blood flow in atherosclerotic rabbits without renal artery stenosis,partly by reducing the serum NO level.

关 键 词：NOREPINEPHRINE ATHEROSCLEROSIS contrast-enhanced ultrasound renal blood flow 

分 类 号：R692[医药卫生—泌尿科学]