小动脉硬化脑血管病危险因素分析及sTM、CD62P、VE-cadherin对其预后的预测  

Analysis of risk factors of arteriosclerotic cerebrovascular disease and prediction of prognosis by STM, CD62P and VE-cadherin

作　　者：李剑侠[1] 林小祥[1] 余勇波 黄先锋 LI Jianxia;LIN Xiaoxiang;YU Yongbo;HUANG Xianfeng(Department of Neurosurgery,Jiangbei Branch,Nanjing Dachang Hospital,Affiliated Zhongda Hospital of Southeast University,Nanjing 210048,Jiangsu,China)

机构地区：[1]东南大学附属中大医院江北院区,南京市大厂医院神经外科,江苏南京210048

出　　处：《中南医学科学杂志》2023年第1期83-86,共4页Medical Science Journal of Central South China

摘　　要：目的 分析小动脉硬化脑血管病的危险因素,及可溶性血栓调节蛋白(sTM)、P选择素(CD62P)、钙黏蛋白(VE-cadherin)对其预后的预测价值。方法 选择小动脉硬化脑血管病患者180例为观察组,根据预后分为预后不良组和预后良好组,另设50例健康者为对照组。检测各组血清sTM、VE-cadherin、CD62P血小板水平,分析其与预后的相关性,以及三者联合检测对预后的评估价值,分析小动脉硬化脑血管病的危险因素。结果 sTM、VE-cadherin、CD62P血小板水平观察组高于对照组,预后不良组高于预后良好组(P<0.05)。sTM、VE-cadherin、CD62P血小板水平与预后呈正相关(P<0.05);三者联合检测对预后的诊断效能高于单独检测(P<0.05)。sTM、VE-cadherin、CD62P血小板水平是小动脉硬化脑血管病的危险因素(P<0.05)。结论 sTM、VE-cadherin、CD62P是小动脉硬化脑血管病的危险因素,三者联合应用对其预后的预测价值较高。Aim To analyze the risk factors of small arteriosclerotic cerebrovascular disease and the predictive value of soluble thrombomodulin(sTM), P-selectin(CD62P) and cadherin(VE-cadherin) on its prognosis. Methods 180 patients with smallarteriosclerosis and cerebrovascular disease were selected as the observation group. According to the prognosis, they were divided into the poor prognosis group and the good prognosis group. Another 50 healthy people were selected as the control group. Serum sTM, VE-cadherin and CD62P platelets levels were detectedin each group, and their correlation with prognosis was analyzed, as well as the evaluation value of the three combined detection on prognosis, and the risk factors of small arteriosclerosis cerebrovascular disease were analyzed. Results The platelet levels of sTM, VE-cadherin and CD62P in the observation group were higher than those in the control group, and those in the poor prognosis group were higher than those in the good prognosis group(P<0.05). The platelet levels of sTM, VE-cadherin and CD62P were positively correlated with prognosis(P<0.05);The diagnostic efficacy of the three combined tests was higher than that of the single test(P<0.05). sTM, VE-cadherin and CD62P platelets were risk factors of arteriosclerotic cerebrovascular disease(P<0.05). Conclusion sTM, VE-cadherin and CD62P are risk factors of arteriosclerotic cerebrovascular disease, and the combined application has high predictive value for its prognosis.

关 键 词：STM CD62P VE-CADHERIN 小动脉硬化脑血管病 危险因素 预后 

分 类 号：R743[医药卫生—神经病学与精神病学]