Dehydrogenation Based Asymmetric Epoxidation of Arylalkanes to Chiral Epoxides  

作　　者：Yiting Su Feng Yu Guixia Liu Zheng Huang 

机构地区：[1]Chang-Kung Chuang Institute,East China Normal University,Shanghai,200062 China [2]State Key Laboratory of Organometallic Chemistry,Center for Excellence in Molecular Synthesis,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,345 Lingling Road,Shanghai,200032 China [3]School of Chemistry and Material Sciences,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,1 Sub-lane Xiangshan,Hangzhou,Zhejiang,310024 China

出　　处：《Chinese Journal of Chemistry》2022年第19期2263-2268,共6页中国化学（英文版）

基　　金：Financial supportfrom the National Key R&D Program of China(Nos.2021YFA1500100,2021YFA1501700);the National Natural Science Foundation of China(Nos.21825109,21821002,21732006,22072178);CAS Youth Interdisciplinary Team(No.JCTD-2021-11);the K.C.Wong Education Foundation,and Ningbo Municipal Bureau of Science and Technology(No.2019B10096)is gratefully acknowledged.

摘　　要：We report herein a formal asymmetric epoxidation of arylalkanes enabled by a one-pot dual-catalysts system comprising a pincer Ir catalyst for alkane dehydrogenation-alkene isomerization(AD-ISO)and a chiral ketone catalyst for asymmetric alkene epoxidation.This protocol provides a catalytic method for the synthesis of aryl epoxides in useful yields with high regio-and stereoselectivity directly from readily available alkyl arenes.Stereospecific derivatizations of the epoxidation product allow access to various enantioenriched compounds.

关 键 词：ALKANES Asymmetric epoxidation DEHYDROGENATION Dual-catalysts IRIDIUM 

分 类 号：O62[理学—有机化学]