长期佩带角膜塑形镜对近视青少年的影响研究  

Effect of Long-term Orthokeratology Correction Therapy on Myopic Adolescents

作　　者：庞宇 刘娟[1] 张俊强 喻谦[1] Pang Yu;Liu Juan;Zhang Junqiang;Yu Qian(Department of Ophthalmology,The First Affiliated Hospital of Chengdu Medical College,Chengdu 610500,China)

机构地区：[1]成都医学院第一附属医院眼科,成都610500

出　　处：《成都医学院学报》2023年第1期74-78,共5页Journal of Chengdu Medical College

摘　　要：目的探讨角膜塑形镜矫正疗法对近视青少年眼表、泪膜功能及生活质量等方面的影响。方法选取2020年1月至2021年6月于成都医学院第一附属医院诊治的近视青少年患者100例为研究对象,根据性别、视力等级等特征采用分层随机抽样法分为试验组(角膜塑形镜矫正治疗)与对照组(单焦框架眼镜矫正治疗),每组50例。评测两组治疗6、12个月的视力情况,分析其眼轴长度、角膜曲率,比较其眼表疾病指数(OSDI)评分、泪膜破裂时间(BUT)及角膜内皮六角形细胞比例;比较两组治疗前和治疗12个月后的生活质量(SF-36)评分情况,并统计两组并发症发生情况。结果治疗6、12个月后,试验组的视力较对照组高,眼轴长度较对照组短,角膜曲率较对照组低,差异均有统计学意义(P<0.05)。试验组治疗6、12个月后的OSDI评分较对照组高,BUT较对照组短,角膜内皮六角形细胞比例较对照组低,并发症发生率较对照组高,差异均有统计学意义(P<0.05)。治疗12个月后两组SF-36各维度评分均提高,且试验组总体健康、生理功能、生理职能、躯体疼痛、活力、社会功能、情感职能及精神健康评分均高于对照组,差异有统计学意义(P<0.05)。结论长期配戴角膜塑形镜有助于改善近视青少年患者的视力、眼轴长度及角膜曲率,提高其生活质量;但同时也会对其眼表、泪膜功能及角膜内皮六角形细胞比例造成不良影响,且会增加其并发症发生率,故临床需做好相应的防治措施。Objective To investigate the effect of orthokeratology correction therapy on the ocular surface,tear film function and quality of life of myopic adolescents.Methods A total of 100 myopic adolescents treated in the First Affiliated Hospital of Chengdu Medical College from January 2020 to June 2021 were selected as the research objects.They were divide into experimental group(n=50,orthokeratology correction therapy)and control group(n=50,single-focalframe glasses correction therapy)by stratified random sampling method according to their gender,visual acuity grade,and other characteristics.After 6 and 12 months of treatment,visual acuity was evaluated,axial length and corneal curvature were analyzed,scores of ocular surface disease index(OSDI),break-up time(BUT),and the proportion of hexagonal cells in the corneal endothelium were compared between the two groups.Quality of life before and 12 months after treatment was evaluated by 36-item short form health survey(SF-36).Incidence of complications in each group was counted.Results After 6 and 12 months of treatment,compared with the control group,the experimental group had higher visual acuity,shorter axial length,and lower corneal curvature,and the differences were statistically significant(P<0.05).After 6 and 12months of treatment,compared with the control group,the experimental group had higher OSDI scores,shorter BUT,lower proportion of hexagonal cells in the corneal endothelium,and higher incidence of complications,and the differences were statistically significant(P<0.05).The scores of each dimension of SF-36 were improved in both groups after 12 months of treatment,and the scores of general health,physiological functioning,role-physical,bodily pain,vitality,social functioning,role-emotional and mental health in the experimental group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Long-term orthokeratology lens wearing can help improve the vision,axial length and corneal curvature

关 键 词：青少年 近视 泪膜功能 眼表功能 角膜塑形镜 

分 类 号：R778.11[医药卫生—眼科]