Salidroside attenuates oxygen and glucose deprivation-induced neuronal injury by inhibiting ferroptosis  

作　　者：Ying-Zhi Li Ai-Ping Wu Dan-Dan Wang Pan-Pan Yang Bin Sheng 

机构地区：[1]Department of Rehabilitation Medicine,Zhejiang Hospital,Hangzhou 310007,Zhejiang,China [2]Department of Emergency Medicine,Zhejiang Provincial People’s Hospital,Hangzhou 310014,Zhejiang,China

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2023年第2期70-79,共10页亚太热带生物医学杂志（英文版）

基　　金：supported by the Zhejiang Traditional Chinese Medicine Science and Technology Plan Project(2021ZB027,2023ZL267);Zhejiang Medical and Health Platform Project of China(2019KY002,2019RC092).

摘　　要：Objective: To evaluate the effect of salidroside on oxygen and glucose deprivation(OGD)-treated NT2 cells and its underlying mechanisms of action.Methods: Retinoic acid was used to induce the differentiation of NT2 cells into neurons. The effects of salidroside on survival, apoptosis, inflammatory response, and oxidative stress of neurons undergoing OGD were evaluated. Using precursor cells as controls, the effect of salidroside on the differentiation progression of OGDtreated cells was evaluated. In addition, the effect of erastin, a ferroptosis inducer, on NT2 cells was examined to investigate the underlying mechanisms of neuroprotective action of salidroside.Results: Salidroside alleviated the effects of OGD on neuronal survival, apoptosis, inflammation, and oxidative stress, and promoted NT2 cell differentiation. Moreover, salidroside prevented ferroptosis of OGD-treated cells, which was abolished following erastin treatment, indicating that ferroptosis mediated the regulatory pathway of salidroside.Conclusions: Salidroside attenuates OGD-induced neuronal injury by inhibiting ferroptosis and promotes neuronal differentiation.

关 键 词：SALIDROSIDE Rhodiola rosea Ferroptosis Oxygen and glucose deprivation Neuronal differentiation Ischemic stroke 

分 类 号：R743.3[医药卫生—神经病学与精神病学]