Neuroprotective effect of mesenchymal stem cellderived extracellular vesicles on optic nerve injury in chronic ocular hypertension  

作　　者：Fei Yu Yao Wang Chang-Quan Huang Si-Jie Lin Ru-Xin Gao Ren-Yi Wu 

机构地区：[1]Department of Glaucoma,Eye Institute and Affiliated Xiamen Eye Center of Xiamen University,School of Medicine,Xiamen University,Xiamen,Fujian Province,China [2]Fujian Provincial Key Laboratory of Corneal&Ocular Surface Diseases,Xiamen,Fujian Province,China [3]Shaanxi Provincial Key Lab of Ophthalmology,Shaanxi Clinical Study Center for Ocular Disease,Shaanxi Institute of Ophthalmology,First Affiliated Hospital,Medical School,Northwest University,Xi’an,Shaanxi Province,China [4]Eye Institute of Xiamen University,Fujian Provincial Key Laboratory of Ophthalmology and Visual Science,Xiamen,Fujian Province,China [5]Department of Glaucoma,Shanghai Peace Eye Hospital,Shanghai,China

出　　处：《Neural Regeneration Research》2023年第10期2301-2306,共6页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,No.81570844;the Natural Science Foundation of Fujian Province,No.2011D001;Medical Innovation Program of Fujian Province,No.2011-CXB-47;Huaxia Translational Medicine Youth Foundation,No.2017-A-00301;Xiamen Science and Technology Program Guiding Project,No.3502Z20189033(all to RYW)。

摘　　要：Mesenchymal stem cells have neuroprotective effects that limit damage to the retina and photoreceptors,and which may be mediated by extracellular vesicles(or exosomes)released by mesenchymal stem cells.To investigate the neuroprotective effect of extracellular vesicles derived from umbilical cord mesenchymal stem cells on glaucoma,we established rat models of chronic ocular hypertension by injecting conjunctival fibroblasts into the anterior chamber to mimic optic nerve injury caused by glaucoma.One week after injury,extracellular vesicles derived from umbilical cord-derived mesenchymal stem cells were injected into the vitreous cavity.We found that extracellular vesicles derived from mesenchymal stem cells substantially reduced retinal damage,increased the number of retinal ganglion cells,and inhibited the activation of caspase-3.These findings suggest that mesenchymal stem cell-derived extracellular vesicles can help alleviate optic nerve injury caused by chronic ocular hypertension,and this effect is achieved by inhibiting cell apoptosis.

关 键 词：animal model APOPTOSIS chronic glaucoma chronic ocular hypertension extracellular vesicles mesenchymal stem cells NEUROPROTECTION rat retinal ganglion cells umbilical cord 

分 类 号：R77[医药卫生—眼科]