Construction and Application of DNAzyme-based Nanodevices  

作　　者：WANG Bo WANG Menghui PENG Fangqi FU Xiaoyi WEN Mei SHI Yuyan CHEN Mei KE Guoliang ZHANG Xiao-Bing 

机构地区：[1]State Key Laboratory of Chemo/Biosensing and Chemometrics,College of Chemistry and Chemical Engineering,Hunan University,Changsha,410082,P.R.China [2]College of Materials Science and Engineering,Hunan University,Changsha,410082,P.R.China [3]Institute of Basic Medicine and Cancer(IBMC),Chinese Academy of Sciences,Hangzhou,310022,P.R.China

出　　处：《Chemical Research in Chinese Universities》2023年第1期42-60,共19页高等学校化学研究（英文版）

基　　金：supported by the National Natural Science Foundation of China (Nos.22122403,22274042,and 21890744);the Natural Science Foundation of Hunan Province,China (Nos.2021JJ10012,2022JJ30121);the Changsha Municipal Natural Science Foundation,China (No.kq2202145).

摘　　要：The development of stimuli-responsive nanodevices with high efficiency and specificity is very important in biosensing,drug delivery,and so on.DNAzymes are a class of DNA molecules with the specific catalytic activity.Owing to their unique catalytic activity and easy design and synthesis,the construction and application of DNAzymes-based nanodevices have attracted much attention in recent years.In this review,the classification and properties of DNAzyme are first introduced.The construction of several common kinds of DNAzyme-based nanodevices,such as DNA motors,signal amplifiers,and logic gates,is then systematically summarized.We also introduce the application of DNAzyme-based nanodevices in sensing and therapeutic fields.In addition,current limitations and future directions are discussed.

关 键 词：DNAZYME NANODEVICE BIOSENSOR THERAPY 

分 类 号：O64[理学—物理化学]