supported by the Huazhong University of Science and Technology(2024JCYJ044 and 2023JCYJ033);the Key Research and Development ProgramofWuhan(2024020702030123);the Major Program(JD)of Hubei Province(2023BAA005);the National Natural Science Foundation of China(92148206 and 82071330);the Research Fund of Tongji Hospital(2022B37).
The brainstem,often referred to as the“vital center of life,”controls functions such as breathing,heartbeat,consciousness,and sensory and motor functions.It is densely packed with structures responsible for critical...
supported financially by the National Natural Science Foundation of China(Nos.T2322005 and 32101156);Youth Innovation Promotion Association CAS.
Efficient delivery of therapeutics to immune cells remains a formidable challenge for cancer immunotherapy.In this work,we demonstrate that an aptamer-driven DNA nanodevice,constructed through linkage of a synthetic i...
Obstruction of blood vessels(thrombosis)due to blood clots is one of the main causes of death worldwide and is associated with many cardiovascular diseases,such as myocardial infarction,ischemic stroke,and pulmonary e...
support from the National Natural Science Foundation of China(82072087,31970893,32270976);funding by Science and Technology Projects in Guangzhou(202206010087,China).
Recently,a work jointly studied by Ling Li and coworkers1 was published in Nature Materials,describing a reconfigurable DNA origami nanodevice designed to regulate CD95 death-inducing signaling of immune cells.The res...
supported by the National Key Research and Development Program of China(Nos.2021YFA0910100,2020YFA0907500);the National Natural Science Foundation of China(Nos.22034002,92253304).
The cell membrane is a critical barrier for cellular homeostasis,integral to signaling and intercellular communication,and vital for understanding cellular functions and disease mechanisms.Investigating its microenvir...
supported by the Natural Science Foundation of China(grant nos.21877030,21735002,and 21778016).
Framework nucleic acids(FNAs)have emerged as intelligent sensing systems for the detection of tumor-related biomarkers in living cells.However,orthogonally controlled manipulation of FNAs-based nanodevices for on-site...
financially supported by the Beijing Natural Science Foundation(JQ20005).
Sensitive and specific imaging of tumor-associated biomarkers offers an effective way for cancer diagnosis.However,most of the reported imaging probes are limited to the targeting of a single biomarker,which may impai...
supported by the National Natural Science Foundation of China (Nos.22122403,22274042,and 21890744);the Natural Science Foundation of Hunan Province,China (Nos.2021JJ10012,2022JJ30121);the Changsha Municipal Natural Science Foundation,China (No.kq2202145).
The development of stimuli-responsive nanodevices with high efficiency and specificity is very important in biosensing,drug delivery,and so on.DNAzymes are a class of DNA molecules with the specific catalytic activity...
the National Natural Science Foundation of China(31922063).
As the use of triboelectric nanogenerators(TENGs)increases,the generation of related electronic waste has been a major challenge.Therefore,the development of environmentally friendly,biodegradable,and low-cost TENGs m...
supported by the National Key Research and Development Program of China (Grant No. 2016YFA0200802);the National Natural Science Fundation of China (Grant No. 11890672)
The fabrication of nanodevices on the delicate membrane window of the TEM(transmission electron microscopy)chip has the risk of breakage failure,limiting in-depth research in this area.This work proposed a methodology...