Effect of cerebralcare granule®combined with donepezil on Alzheimer’s disease  

作　　者：Ming-Juan Yang Ou Qiao Du-Hong Xie Xin-Yu Zhang Ya-Ping Bo Xia Li Juan Wang Wen-Yuan Gao 

机构地区：[1]School of Pharmaceutical Science and Technology,Tianjin University,Tianjin 300072,China [2]Clinical college,Changsha Health Vocational College,Changsha 410100,China

出　　处：《Drug Combination Therapy》2023年第1期10-18,共9页药物联合治疗

基　　金：supported by the Innovation Team and Talents Cultivation Program of the National Administration of Traditional Chinese Medicine[grant numbers ZYYCXTD-D-202005];the Key Project at Central Government Level[grant numbers 2060302];the Special Project for Transformation of Scientific and Technological Achievements in Qinghai Province[grant numbers 2021-SF-150].

摘　　要：Background:The current prevalence of Alzheimer’s disease(AD)in the elderly has risen from 1%at 65 to 40%to 50%at 95,and the overall proportion is rising.Emerging evidence suggests that ros-driven oxidative stress is a crucial mediator of the aging process.Thus,in recent years,oxidative damage and inflammation have become targets for exploring pharmacological strategies for treating age-related diseases.Methods:In C57BL/6J mice,to determine whether the mechanism of action of cerebralcare granule®(CG)combined with donepezil(Don)treatment is better than dementia alone,we constructed a mouse model and treated it with CG in combination with Don.Results:A combination of Don and CG significantly reduces the damage caused by lipid peroxidation in the hippocampus of AD mice,reduces oxidative damage,and reduces inflammation,increases the activity of antioxidant enzymes,which is finally manifested as the improvement effect on the learning and memory impairment of AD mice.Conclusion:CG combined with Don has a better effect on improving cognitive and behavioral deficits caused by D-galactose in AD mice than Don alone.The mechanism may be related to reducing inflammation via the NF-κB pathway,resisting oxidative damage and increasing acetylcholine levels.

关 键 词：Alzheimer’s disease cerebralcare granule® DONEPEZIL drug combination 

分 类 号：R74[医药卫生—神经病学与精神病学]