55对不良孕产史夫妇的细胞遗传学研究  

Cytogenetics Study on Couples with Poor Pregnancy and Childbirth History

作　　者：曾南阳 谢妍 洪钦明 王彧 ZENG Nanyang;XIE Yan;HONG Qinming;WANG Yu(Clinical Laboratory,Rongcheng District Maternal and Child Health and Family Planning Service Center,Jieyang,Guangdong,522000;Prenatal Diagnosis Reproductive Health Care Center of Laboratory,Rongcheng District Maternal and Child Health and Family Planning Service Center,Jieyang,Guangdong,522000)

机构地区：[1]广东省揭阳市榕城区妇幼保健计划生育服务中心检验科,广东揭阳522000 [2]广东省揭阳市榕城区妇幼保健计划生育服务中心产前诊断生殖保健中心,广东揭阳522000

出　　处：《智慧健康》2022年第34期143-147,共5页Smart Healthcare

基　　金：揭阳市科技计划项目,“不良孕产史夫妇的细胞遗传学研究”(项目编号:YLWS048)。

摘　　要：目的探讨不良孕产史夫妇染色体异常的发病率,及筛查外周血染色体的意义。方法选取2019年5月-2021年2月于广东省揭阳市榕城区妇幼保健计划生育服务中心治疗的不良孕产史夫妇110例(55对)作为研究对象,抽取其静脉血,培养淋巴细胞,进行G显带处理,分析核型。比较不同性别及流产次数同染色体异常检出率的关系。结果在110例不良孕产史夫妇中,22例出现染色体异常,占比20.00%。其中7例平衡易位,占比31.82%(7/22);15例正常变异,占比68.18%(15/22)。正常变异中,2例染色体倒位,占比13.33%(2/15);13例染色体多态性,占比86.67%(13/15);不同性别染色体异常检出率对比,差异无统计学意义(P>0.05);不同流产次数染色体异常检出率对比,差异无统计学意义(P>0.05)。结论染色体异常为造成不良孕产的一个重要原因,细胞遗传学研究对于明确不良孕产史夫妇的病因有帮助。Objective To explore the incidence of chromosomal abnormalities in couples with a history of poor pregnancy and childbirth,and the significance of screening peripheral blood chromosomes.Methods The study selected 110 couples(55 pairs)with poor maternity history who were treated in Maternal and Child Health and Family Planning Service Center,Rongcheng District,Jieyang City,Guangdong Province from May 2019 to February 2021 as the research objects.Venous blood was drawn,lymphocytes were cultured,G banding,and the karyotype was analyzed,if necessary N band or C band was added.The relationship between different genders and the number of miscarriages and the detection rate of chromosomal abnormalities were compared.Results Among 110 couples with poor pregnancy and birth history,22 had chromosomal abnormalities,accounting for 20.00%.Among them,there were 7 cases of balanced translocation,accounting for 31.82%(7/22);15 cases of normal mutation,accounting for 68.18%(15/22).Among normal mutations,there were 2 cases of chromosome inversions,accounting for 13.33%(2/15);13 chromosome polymorphisms,accounting for 86.67%(13/15);there was no significant difference in the detection rates of chromosomal abnormalities between different sexes(P>0.05);there was no significant difference in the detection rates of chromosomal abnormalities in different abortion times(P>0.05).Conclusion Chromosomal abnormalities are an important cause of poor pregnancy and childbirth,and cytogenetic research is helpful to clarify the etiology of couples with poor pregnancy and childbirth history.

关 键 词：不良孕产史 细胞遗传学 染色体异常 发病率 外周血染色体 

分 类 号：R714.5[医药卫生—妇产科学] R440[医药卫生—临床医学]