Therapeutic interventions of acute and chronic liver disorders:A comprehensive review  

作　　者：Fares EM Ali Mostafa K Abd El-Aziz Elham I Sharab Adel G Bakr 

机构地区：[1]Department of Pharmacology and Toxicology,Faculty of Pharmacy,Al-Azhar University,Assiut Branch,Assiut 71524,Egypt [2]Faculty of Pharmacy,Al-Azhar University,Assiut Branch,Assiut 71524,Egypt

出　　处：《World Journal of Hepatology》2023年第1期19-40,共22页世界肝病学杂志（英文版）（电子版）

摘　　要：Liver disorders are one of the most common pathological problems worldwide.It affects more than 1.5 billion worldwide.Many types of hepatic cells have been reported to be involved in the initiation and propagation of both acute and chronic liver diseases,including hepatocytes,Kupffer cells,sinusoidal endothelial cells,and hepatic stellate cells(HSCs).In addition,oxidative stress,cytokines,fibrogenic factors,microRNAs,and autophagy are also involved.Understanding the molecular mechanisms of liver diseases leads to discovering new therapeutic interventions that can be used in clinics.Recently,antioxidant,anti-inflammatory,anti-HSCs therapy,gene therapy,cell therapy,gut microbiota,and nanoparticles have great potential for preventing and treating liver diseases.Here,we explored the recent possible molecular mechanisms involved in the pathogenesis of acute and chronic liver diseases.Besides,we overviewed the recent therapeutic interventions that targeted liver diseases and summarized the recent studies concerning liver disorders therapy.

关 键 词：Liver disorders AUTOPHAGY Gene therapy Anti-hepatic stellate cells Cell therapy 

分 类 号：R575[医药卫生—消化系统]