Could there be an interplay between periodontal changes and pancreatic malignancies?  

作　　者：Bogdan Silviu Ungureanu Dorin Nicolae Gheorghe Flavia Mirela Nicolae Sandu Ramboiu Petru Adrian Radu Valeriu MarinȘurlin Victor Dan Eugen Strambu Dan Ionut Gheonea Alexandra Roman PetraȘurlin 

机构地区：[1]Department of Gastroenterology,University of Medicine and Pharmacy of Craiova,Craiova 200349,Romania [2]Department of Periodontology,Research Center of Periodontal-Systemic Implications,University of Medicine and Pharmacy of Craiova,Craiova 200349,Romania [3]Department 1st of Surgery,University of Medicine and Pharmacy of Craiova,Craiova 200349,Romania [4]Department of General Surgery,“Carol Davila”University of Medicine and Pharmacy,Bucharest 020021,Romania [5]Department of Periodontology,"Iuliu Hațieganu"University of Medicine and Pharmacy,Cluj-Napoca 400012,Romania

出　　处：《World Journal of Clinical Cases》2023年第3期545-555,共11页世界临床病例杂志

摘　　要：The term"periodontal disease"refers to a group of chronic inflammatory illnesses caused by specific microorganisms from subgingival biofilm,that affect the toothsupporting tissues.Recent research has also shown that periodontal infection plays a role in aggravating systemic disease states at distal sites,reinforcing the significance of the oral cavity for general health.Additionally,it has been suggested that gastroenterological malignancies may be promoted by hematogenous,enteral or lymphatic translocation of periopathogens.In the past 25 years,the global burden of pancreatic cancer(PC)has more than doubled,making it one of the major causes of cancer-related mortality.Periodontitis has been linked to at least 50%increased risk of PC and it could be considered a risk factor for this malignancy.A recent study performed on 59000 African American women with a follow up of 21 years showed that participants who had poor dental health had higher chances of PC.The findings,according to researchers,might be related to the inflammation that some oral bacteria trigger.Regarding the mortality of PC,periodontitis considerably raises the chance of dying from PC.Microbiome alterations in the gut,oral cavity and pancreatic tissues of PC patients occur when compared to healthy flora,demonstrating a link between PC and microecology.Inflammation may also contribute to PC development,although the underlying pathway is not yet known.The function of the microbiome in PC risk has drawn more focus over the last decade.Future risk of PC has been linked to the oral microbiome,specifically increased levels of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans and decreased relative abundance of Leptotrichia and Fusobacteria,suggesting that it may have an impact on the inflammatory condition by expanding,altering,and regulating the commensal microbiome.Patients who received periodontal treatment had significantly decreased incidence rate ratios for PC.By analyzing patterns in the microbiome composition throughout PC develop

关 键 词：Periodontal disease Pancreatic cancer MICROBIOME PERIODONTITIS Periopathogens Periodontal medicine 

分 类 号：R735.9[医药卫生—肿瘤]