Future applications of exosomes delivering resolvins and cytokines in facilitating diabetic foot ulcer healing  

作　　者：Joshua P B Littig Rebecca Moellmer Devendra K Agrawal Vikrant Rai 

机构地区：[1]Translational Research,Western University of Health Sciences,Pomona,CA 91766,United States [2]College of Podiatry,Western University of Health Sciences,Pomona,CA 91766,United States

出　　处：《World Journal of Diabetes》2023年第1期35-47,共13页世界糖尿病杂志（英文版）（电子版）

基　　金：Supported by the Intramural Grant IMR Rai 12397B from the Western University of Health Sciences,Pomona,California;the Grants from the National Institutes of Health,United States,R01 HL144125 and R01 HL147662.

摘　　要：Type 2 diabetes mellitus(T2DM)increases the risk of many lethal and debilitating conditions.Among them,foot ulceration due to neuropathy,vascular disease,or trauma affects the quality of life of millions in the United States and around the world.Physiological wound healing is stalled in the inflammatory phase by the chronicity of inflammation without proceeding to the resolution phase.Despite advanced treatment,diabetic foot ulcers(DFUs)are associated with a risk of amputation.Thus,there is a need for novel therapies to address chronic inflammation,decreased angiogenesis,and impaired granulation tissue formation contributing to the non-healing of DFUs.Studies have shown promising results with resolvins(Rv)and anti-inflammatory therapies that resolve inflammation and enhance tissue healing.But many of these studies have encountered difficulty in the delivery of Rv in terms of efficiency,tissue targetability,and immunogenicity.This review summarized the perspective of optimizing the therapeutic application of Rv and cytokines by pairing them with exosomes as a novel strategy for targeted tissue delivery to treat non-healing chronic DFUs.The articles discussing the T2DM disease state,current research on Rv for treating inflammation,the role of Rv in enhancing wound healing,and exosomes as a delivery vehicle were critically reviewed to find support for the proposition of using Rv and exosomes in combination for DFUs therapy.The literature reviewed suggests the beneficial role of Rv and exosomes and exosomes loaded with antiinflammatory agents as promising therapeutic agents in ulcer healing.

关 键 词：Diabetic foot ulcer Chronic inflammation AMPUTATION EXOSOMES CYTOKINES RESOLVINS 

分 类 号：R587.2[医药卫生—内分泌]