Risk of critical limb ischemia in long-term uterine cancer survivors:A population-based study  

作　　者：Min-Chi Chen Jung-Jung Chang Miao-Fen Chen Ting-Yao Wang Cih-En Huang Kuan-Der Lee Chao-Yu Chen 

机构地区：[1]Department of Public Health,Chang Gung University,Taoyuan 333,Taiwan [2]Department of Obstetrics and Gynecology,Chang Gung Memorial Hospital,Chiayi 612,Taiwan [3]Division of Cardiovascular Disease,Department of Internal Medicine,Chang Gung Memorial Hospital,Chiayi 612,Taiwan [4]Department of Radiation Oncology,Change Gung Memorial Hospital,Linkou,Taoyuan 333,Taiwan [5]Division of Hematology and Oncology,Department of Internal Medicine,Chang Gung Memorial Hospital,Chiayi 612,Taiwan [6]Graduate Institute of Clinical Medical Sciences,College of Medicine,Chang Gung University,Taoyuan 333,Taiwan [7]Department of Medicine,Taipei Medical University Hospital,Taipei 100,Taiwan [8]Department of Medical Research,Taichung Veterans General Hospital,Taichung 407,Taiwan [9]Department of Post-Baccalaureate Medicine,College of Medicine,National Chung Hsing University,Taichung 402,Taiwan [10]Department of Early Childhood Care and Education,Shu-Zen Junior College of Medicine and Management,Kaohsiung 821,Taiwan

出　　处：《World Journal of Clinical Cases》2022年第36期13293-13303,共11页世界临床病例杂志

基　　金：Supported by the Chang Gung Medical Foundation,Taiwan,No.CMRPD1J0101-0102。

摘　　要：BACKGROUND The risk of critical limb ischemia(CLI)which causes ischemic pain or ischemic loss in the arteries of the lower extremities in long-term uterine cancer(UC)survivors remains unclear,especially in Asian patients,who are younger at the diagnosis of UC than their Western counterparts.AIM To conduct a nationwide population-based study to assess the risk of CLI in UC long-term survivors.METHODS UC survivors,defined as those who survived for longer than 5 years after the diagnosis,were identified and matched at a 1:4 ratio with normal controls.Stratified Cox models were used to assess the risk of CLI.RESULTS From 2000 to 2005,1889 UC survivors who received surgery alone or surgery combined with radiotherapy(RT)were classified into younger(onset age<50 years,n=894)and older(onset age≥50 years,n=995)groups.While compared with normal controls,the younger patients with diabetes,hypertension,and receiving hormone replacement therapy(HRT)were more likely to develop CLI.In contrast,the risk of CLI was associated with adjuvant RT,obesity,hypertension,and HRT in the older group.Among the UC survivors,those who were diagnosed at an advanced age(>65 years,aHR=2.48,P=0.011),had hypertension(aHR=2.18,P=0.008)or received HRT(aHR=3.52,P=0.020)were at a higher risk of CLI.CONCLUSION In this nationwide study,we found that the risk factors associated with CLI were similar in both cohorts except for adjuvant RT that was negligible in the younger group,but positive in the older group.Among the survivors,hypertension,advanced age,and HRT were more hazardous than RT.Secondary prevention should include CLI as a late complication in UC survivorship programs.

关 键 词：Uterine cancer Critical limb ischemia RADIOTHERAPY SURVIVORSHIP 

分 类 号：R737.33[医药卫生—肿瘤]