Ihog proteins contribute to integrin-mediated focal adhesions  

作　　者：Yun Qi Han Liu Kang Zhang Yihui Wu Chenghao Shen Xinhua Lin 

机构地区：[1]The State Key Laboratory of Genetic Engineering,Institute of Genetics,School of Life Sciences,Fudan University,Shanghai 200433,China [2]The State Key Laboratory of Membrane Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100864,China [3]Current Address:Human Phenome Institute,Fudan University,Shanghai 200433,China

出　　处：《Science China(Life Sciences)》2023年第2期366-375,共10页中国科学（生命科学英文版）

基　　金：supported by National Natural Science Foundation of China (91754109, 31771544, 31730044)。

摘　　要：Integrin expression forms focal adhesions, but how this process is physiologically regulated is unclear. Ihog proteins are evolutionarily conserved, playing roles in Hedgehog signaling and serving as trans-homophilic adhesion molecules to mediate cell-cell interactions. Whether these proteins are also engaged in other cell adhesion processes remains unknown. Here, we report that Drosophila Ihog proteins function in the integrin-mediated adhesions. Removal of Ihog proteins causes blister and spheroidal muscle in wings and embryos, respectively. We demonstrate that Ihog proteins interact with integrin via the extracellular portion and that their removal perturbs integrin distribution. Finally, we show that Boc, a mammalian Ihog protein,rescues the embryonic defects caused by removing its Drosophila homologs. We thus propose that Ihog proteins contribute to integrin-mediated focal adhesions.

关 键 词：INTEGRIN focal adhesion Ihog/Boi DROSOPHILA 

分 类 号：Q943.2[生物学—植物学]