Formyl peptide receptor 2 as a potential therapeutic target for inflammatory bowel disease  

作　　者：Wen-sheng Yang Jing-lin Wang Wei Wu Guang-fei Wang Jun Yan Qing Liu Xiao-yan Wu Qing-tong Zhou De-hua Yang Ming-Wei Wang Zhi-ping Li 

机构地区：[1]Department of Pharmacy,Children’s Hospital of Fudan University,National Children’s Medical Center,Shanghai,201102,China [2]Department of Pharmacy,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430022,China [3]Department of Laboratory Animal Science,Fudan University,Shanghai,200032,China [4]The National Center for Drug Screening,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,201203,China [5]Research Center for Deepsea Bioresources,Sanya,572025,China [6]Department of Pharmacology,School of Basic Medical Sciences,Fudan University,Shanghai,200032,China

出　　处：《Acta Pharmacologica Sinica》2023年第1期19-31,共13页中国药理学报（英文版）

基　　金：This work was partially supported by National Natural Science Foundation of China 81874325(Zhi-ping Li),81872915(Ming-Wei Wang),82073904(Ming-Wei Wang),81973373(De-hua Yang),82121005(De-hua Yang)and 21704064(Qing-tong Zhou);The Science and Technology Commission of Shanghai Municipality 18DZ1910604(Zhi-ping Li),19XD1400900(Zhi-ping Li)and 19DZ1910604(Zhi-ping Li);National Science and Technology Major Project of China-Key New Drug Creation and Manufacturing Program 2018ZX09735-001(Ming-Wei Wang),2018ZX09711002-002-005(De-hua Yang)and 2018ZX09711002-002-011(Qing Liu);the National Key Basic Research Program of China 2018YFA0507000 (Ming-Wei Wang).

摘　　要：Inflammatory bowel disease(IBD)is a global health burden whose existing treatment is largely dependent on anti-inflammatory agents.Despite showing some therapeutic actions,their clinical efficacy and adverse events are unacceptable.Resolution as an active and orchestrated phase of inflammation involves improper inflammatory response with three key triggers,specialized pro-resolving mediators(SPMs),neutrophils and phagocyte efferocytosis.The formyl peptide receptor 2(FPR2/ALX)is a human G protein-coupled receptor capable of binding SPMs and participates in the resolution process.This receptor has been implicated in several inflammatory diseases and its association with mouse model of IBD was established in some resolution-related studies.Here,we give an overview of three reported FPR2/ALX agonists highlighting their respective roles in pro-resolving strategies.

关 键 词：RESOLUTION INFLAMMATION FPR2/ALX SPM IBD pro-resolving 

分 类 号：R57[医药卫生—消化系统]