海参粉微丸制备工艺  

Preparation Technology of Sea Cucumber Powder Pellets

作　　者：喻樊[1,2,3,4] 蔡蓉 蔡伶丽 YU Fan;CAI Rong;CAI Lingli(Jiangsu Province Engineering Research Center of Tumor Targeted Nano Diagnostic and Therapeutic Materials,Yancheng Teachers University,Yancheng 224007;College of Pharmacy,Yancheng Teachers University,Yancheng 224051;Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection,Yancheng 224002;Nanjing University of Technology,Nanjing 210000)

机构地区：[1]江苏省肿瘤靶向纳米诊疗材料工程研究中心,盐城师范学院,盐城224007 [2]药学院盐城师范学院,盐城224051 [3]江苏省滩涂生物资源与环境保护重点建设实验室,盐城224002 [4]南京工业大学,南京210000

出　　处：《食品工业》2023年第1期8-12,共5页The Food Industry

基　　金：江苏省自然科学基金面上项目(编号:BK20221409);江苏省肿瘤靶向纳米诊疗材料工程研究中心开放基金资助(编号:JETNM202208);江苏省盐土生物资源研究重点实验室项目(JKLBS2015008);盐城市农业科技创新专项引导资金项目(编号:YKN2016011);江苏省海洋滩涂生物化学与生物技术重点建设实验室项目(K2016-12);盐城师范学院拔尖人才计划项目;江苏省大学生创新创业重点计划项目(编号:202010324025Z)。

摘　　要：研究海参粉微丸的制备工艺。采用挤出滚圆法制备海参粉微丸;以圆整度为主要指标,采用单因素试验筛选最优制备工艺参数;考察微丸的粉体学性质;用红外光谱法、X射线衍射法、扫描电子显微镜法等方法对微丸进行表征。结果表明,挤出滚圆法最佳工艺参数为挤出频率30 Hz、滚圆频率50 Hz、滚圆时间4 min。制备的海参粉微丸圆整度、流动性及堆密度均较好,且药物高度分散于微丸中。采用优化的工艺参数,利用挤出滚圆法制备海参粉微丸,简单易行,可用于生产。Study the preparation technology of sea cucumber powder pellets. The sea cucumber powder pellets were prepared by extrusion spheronization method. The optimal preparation parameters were obtained by single factor experiment.Micromeritic properties were determined. The pellets were characterized by infrared spectroscopy, X-ray diffraction and scanning electron microscopy. The optimum technology parameters were as follows: extrusion velocity of 30 Hz,spheronization velocity of 50 Hz, and spheronization time of 4 min. The sea cucumber powder pellets prepared by extrusion spheronization method were all good of roundness, fluidity and density. The drug is highly dispersed in the pellets. Using the optimized parameters, the preparation of sea cucumber powder pellets by extrusion spheronization method is simple and can be used for production.

关 键 词：海参粉 微丸 挤出滚圆法 粉体学性质 表征 

分 类 号：TS254.4[轻工技术与工程—水产品加工及贮藏工程]