NR2B亚基磷酸化在缺血/低氧神经保护中的作用  

Effects of N-methyl-D-aspartate receptor NR2B phosphorylation on ischemic/hypoxic neuroprotection

作　　者：刘晓蕾 姜树原 邵国 谢雅彬 贾小娥 谢伟 LIU Xiaolei;JIANG Shuyuan;SHAO Guo;XIE Yabin;JIA Xiaoe;XIE Wei(School of Pharmacy,Baotou Medical College,Baotou 014040,China;Inner Mongolia Key Laboratory of Hypoxic Translational Medicine,Baotou 014040;Department of Public Health,International College,Krirk University,Bangkok 10220,Thailand;Center for Translational Medicine and Department of Laboratory Medicine,the Third People’s Hospital of Longgang District Shenzhen,Shenzhen 518112)

机构地区：[1]包头医学院药学院,内蒙古包头014040 [2]内蒙古自治区低氧转化医学重点实验室,内蒙古包头014040 [3]泰国格乐大学国际学院公共卫生学系,泰国曼谷10220 [4]深圳市龙岗区第三人民医院转化医学中心检验科,广东深圳518112

出　　处：《中国比较医学杂志》2023年第1期125-129,共5页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金(82060337,82071479,31860307);内蒙古自然科学基金项目(2020MS08171,2020MS08172,2020MS08006);深圳市龙岗区医疗卫生科技计划项目(LGKCYLWS2021000033);深圳市科技计划项目基础研究面上项目(JCYJ20220531092412028);包头医学院科学研究基金资助项目(BYJJ-YF201719,BYJJ-QM-2018004)。

摘　　要：N-甲基-D-天冬氨酸(NMDA)受体在神经系统功能中起着关键作用。NR2B亚基是NMDA受体的调节亚单位,在低氧/缺血神经保护中有重要作用。NR2B磷酸化是调节NMDA受体功能的重要机制,通过磷酸化的变化在缺血/低氧神经保护中发挥重要作用。本文综述了NMDA受体NR2B亚基的结构、功能、磷酸化、信号通路与缺血/低氧神经保护的关系,为以NR2B亚基为靶点进行低氧/缺血脑疾病的防治工作提供思路。N-methyl-D-aspartate(NMDA)receptor plays an important role in the function of the nervous system.The NR2B subunit is the regulatory subunit of NMDA receptor,which is closely related to the neuroprotection of hypoxia/ischemia.Phosphorylation of NR2B is considered to be an important mechanism to regulate the NMDA receptor function and plays an important role in ischemic/hypoxic neuroprotection through the change in phosphorylation.This review discusses the development of the NR2B subunit of NMDA receptor and the relationships between the structure,function,phosphorylation,signaling pathway and ischemic/hypoxic neuroprotection to provide a theoretical foundation to prevent and treat hypoxic/ischemic brain diseases with NR2B subunit as the target.

关 键 词：NMDA NR2B 缺血/低氧 磷酸化 神经保护 

分 类 号：R-33[医药卫生]