高校实验动物中心动物质量控制研究与创新实践  

Research and innovation in the practice of animal quality control in a university laboratory animal center

作　　者：张志妮 杨力衡 严楚 蔡卫斌[1] ZHANG Zhini;YANG Liheng;YAN Chu;CAI Weibin(Laboratory Animal Center,Sun Yat-Sen University,Guangzhou 510006,China;Animal Husbandry and Veterinary Station of Guangzhou Baiyun District,Guangzhou 510550)

机构地区：[1]中山大学实验动物中心,广州510006 [2]广州市白云区畜牧兽医站,广州510550

出　　处：《中国比较医学杂志》2022年第12期77-81,共5页Chinese Journal of Comparative Medicine

基　　金：国家重点研发计划(2019YFA0801403);国家自然科学基金(82170261,81970219,82000250);广东省自然科学科学基金(2021A1515011005,2021B1212040006);中国博士后基金(2020M672976)。

摘　　要：目的实验动物质量直接关系着研究和评价数据的准确性和可重复性,亦是公共卫生安全的主要部分。方法针对高校动物中心来源复杂、人员流动性大、需求多样等特点,从管理体系建立和病原检测角度提升实验动物质量。结果建立并执行了实验动物准入制度、哨兵动物监测制度、动物用品监测制度等系列管理体系,自2018年以来,检测了1481批次非活体动物样本,106批次病原阳性,检测了395例活体动物样本,38例病原阳性,检测了363份动物相关用品。结论禁止了数批烈性传染病病原阳性动物的进入、严密监视了条件致病菌阳性动物的来源单位、及时调整和更新了大小鼠监测病原谱,从而提升了实验动物质量。Objective The quality of laboratory animals directly affects the quality of data they provide and has a substantial impact on public health and safety.Methods To improve the quality of laboratory animals,a management system and pathogen-detection scheme were implemented for the unique conditions in a university laboratory animal center with animals from different sources and high personnel traffic.Results The laboratory animal accreditation system,etiology surveillance system and animal-related supplies,was established and implemented.Since 2018,1481 non-living animal samples were detected,106 of which were pathogen-positive.In addition,395 live animal samples were detected,38 of which were pathogen-positive.A total of 363 animal-related supplies were monitored.Conclusions Several severe infectious-disease-agent-positive animals were forbidden to enter;opportunistic-agent-positive supply units were closely monitored;and the objective monitoring of pathogen genealogy in rats and mice was adjusted and updated.Hence,the quality of the laboratory animals was evaluated in time to prevent false result.

关 键 词：实验动物 质量控制 病原 高校 

分 类 号：R-33[医药卫生]