壳聚糖基微球在口腔组织病损治疗中的研究进展  

Progress of research on chitosan-based microspheres in oral tissue lesions

作　　者：周华俊 丁榆德 杨帆[2] ZHOU Huajun;DING Yude;YANG Fan(School of Stomatology,Zhejiang Chinese Medical University,Hangzhou 310053,China)

机构地区：[1]浙江中医药大学口腔医学院,浙江杭州310053 [2]浙江省人民医院口腔医学中心,浙江杭州310014

出　　处：《口腔医学》2023年第1期92-96,共5页Stomatology

基　　金：浙江省医药卫生科研计划(2020KY010);浙江省中医药科技计划(2023ZL242,2019ZA014)。

摘　　要：壳聚糖基微球是以壳聚糖为主要材料,通过微球加工技术得到的具有特殊结构的微粒。它具有良好的缓控释药物能力,可提供支架作用,在口腔临床治疗中具有很大的应用前景,但目前仍处于研究阶段,尚未应用于临床。该文就目前国内外对于壳聚糖基微球在口腔颌骨组织缺损、牙周病损、牙体牙髓病变及神经组织损伤治疗方面的研究进展作一综述,为后续研究及最终实现临床应用提供参考。Chitosan-based microspheres use chitosan as the main material to obtain particles with special structures through microsphere processing technology.They have the ability of slow and controlled release of drugs and the role of scaffolding,which have great application prospect in stomatology,but the application of chitosan-based microspheres is still in the research stage and has not yet been applied in clinical practice.This article reviews progress of domestic and foreign research on chitosan-based microspheres,in aspects of treatment of oral and jawbone tissue defects,periodontal diseases,dental pulp diseases and nerve tissue injury,in order to provide reference for follow-up research.

关 键 词：壳聚糖基微球 载药 缓释 口腔组织 

分 类 号：R780.1[医药卫生—口腔医学]