Surface Bioactive Modification of Alumina Ceramic by Mineralization in Modified SBF  

作　　者：Wenmin Zhang Caixia Liang Qixuan He Xiaoyan Cao Fangli Yuan Jiandong Ye 

机构地区：[1]School of Material Science and Engineering,South China University of Technology,Guangzhou,510640,China [2]National Engineering Research Center for Tissue Restoration and Reconstruction,Guangzhou,510006,China [3]Guangdong Fapon Biotech Co.Ltd,Dongguan,523808,China [4]Inspection and Quarantine Comprehensive Technology Centre of Foshan Entry‐exit Inspection and Quarantine Bureau,Foshan,528042,China [5]Key Laboratory of Biomedical Materials of Ministry of Education,South China University of Technology,Guangzhou,510641,China

出　　处：《Journal of Bionic Engineering》2022年第6期1637-1644,共8页仿生工程学报（英文版）

基　　金：National Natural Science Foundation of China(Grant no.52172280);National Key R&D Program of China(Grant no.2016YFB0700803).

摘　　要：In the present study,it is found that the prepared alumina ceramics has better mineralization ability in a newly revised simulated body fluid.With the extension of mineralization time,the amount of hydroxyapatite(HA)crystals deposited on the surface of alumina ceramics also increased gradually.The results of cell biological experiments of alumina ceramics with hydroxyapatite surface layer demonstrate that the mineralized materials have better biological activity and osteogenesis properties in vitro.In the meanwhile,the ALP activity and expression of osteogenesis-related genes(OPN,ALP,Col-I,and OCN)of mouse bone marrow stromal stem cells on the samples were significantly promoted by increasing the formation of HA on the surface of alumina ceramics.Our research concluded that alumina ceramics with HA phase on surface had great potential to be developed as a sort of bioactive material in the bone repair field.

关 键 词：ALUMINA BIOMATERIALS MINERALIZATION HYDROXYAPATITE OSTEOBLASTS 

分 类 号：TQ174[化学工程—陶瓷工业]