大鲵肽复合粉用于胃肠道恶性肿瘤患者营养支持的临床效果及安全性研究  

Clinical effect and security research of Andrias davidianus peptide composite powder applied for the nutritional support of patients with gastrointestinal cancer

作　　者：吴松岩 于登峰[3] 张峰[4] 刘剑文 李伟 佟长青 翟兴月[2] WU Songyan;YU Dengfeng;ZHANG Feng;LIU Jianwen;LI Wei;TONG Changqing;ZHAI Xingyue(College of Food Science and Engineering,Dalian Ocean University,Dalian,Liaoning 116023,China;Clinical Nutrition Department,The Second Hospital of Dalian Medical University,Dalian,Liaoning 116023,China;The First Department of Anorectum,Dalian University Affiliated Xinhua Hospital,Dalian,Liaoning 116021,China;The First Department of Gastroenterology,The Second Hospital of Dalian Medical University,Dalian,Liaoning 116023,China)

机构地区：[1]大连海洋大学食品科学与工程学院,辽宁大连116023 [2]大连医科大学附属第二医院临床营养科,辽宁大连116023 [3]大连大学附属新华医院肛肠一科,辽宁大连116021 [4]大连医科大学附属第二医院胃肠外一科,辽宁大连116023

出　　处：《现代医学与健康研究电子杂志》2023年第6期28-31,共4页Modern Medicine and Health Research

基　　金：大连医科大学附属第二医院“1+X”计划临床技术水平提升项目(编号:2022LCJSGC19)。

摘　　要：目的探讨大鲵肽复合粉在胃肠道恶性肿瘤患者中的应用效果,为肠内营养支持方案的制定提供科学依据。方法选取大连医科大学附属第二医院于2022年4月至9月期间进行治疗的胃肠道恶性肿瘤患者46例,以随机数字表法分为两组,各23例。给予对照组患者常规营养支持治疗,试验组患者在对照组的基础上联合大鲵肽复合粉治疗,两组患者均治疗21 d。对比两组患者治疗前后的营养状况[血清白蛋白(ALB)、总蛋白(TP)、前白蛋白(PA)]、肝功能[血清γ-谷氨酰转移酶(GGT)、天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)]及肾功能[尿素(Urea)、肌酐(Cr)、尿酸(UA)]指标水平。结果与治疗前比,治疗后对照组患者血清ALB、TP及两组患者血清PA水平均显著降低,但治疗后试验组患者血清ALB、TP水平均显著高于对照组(均P<0.05);试验组患者治疗前后血清ALB、TP及治疗后两组患者PA比较,差异均无统计学意义(均P>0.05);两组患者血清GGT、AST、ALT及Urea、Cr、UA水平组内与组间比较,差异均无统计学意义(均P>0.05);试验组和对照组患者在治疗期间均未见腹泻、腹胀、过敏等不良反应发生。结论胃肠道恶性肿瘤患者在手术治疗之后,口服补充大鲵肽复合粉行肠内营养支持,有效地改善了患者的营养状况,且对肝、肾功能影响不大,安全性良好,有利于患者术后的康复。Objective To explore the application effect of Andrias davidianus peptide composite powder for the patients with gastrointestinal cancer,and provide reference for making the treatment program of nutritional support.Methods A total of 46 patients with gastrointestinal cancer treated in the Second Hospital of Dalian Medical University from April to September 2022 were divided into the two groups according to the random number table method,23 cases for each group.Patients in the control group were given routine nutritional support treatment,and patients in the test group were treated with Andrias davidianus peptide composite powder on the basis of the control group,both groups were treated for 21 days.The levels of the nutritional status indexes[serum albumin(ALB),total protein(TP),prealbumin(PA)],liver function indexes[serum gamma-glutamyltransferase(GGT),aspartate aminotransferase(AST),alanine aminotransferase(ALT)]and renal function indexes[urea(Urea),creatinine(Cr),uric acid(UA)]of patients in the two groups before and after treatment were compared.Results Compared with before treatment,the levels of serum ALB and TP of patients in the control group and the levels of serum PA of patients in the two groups significantly decreased after treatment,but the levels of serum ALB and TP of patients in the test group after treatment were significantly higher than those in the control group(all P<0.05);the comparisons of the levels of serum ALB,TP of patients in the test group before and after treatment,and the levels of PA of patients in the two groups after treatment,the difference was not statistically significant(all P>0.05);the intra-group and the inter-group comparision of the levels of serum GGT,AST,ALT,Urea,Cr and UA of patients,the difference was not statistically significant(all P>0.05);there was no adverse reactions such as diarrhea,abdominal distension and allergy were found among the patients in the test group and the control group during the treatment.Conclusion Patients with gastrointestinal cancer oral sup

关 键 词：胃肠道恶性肿瘤 肠内营养 大鲵肽 营养状况 肝功能 肾功能 

分 类 号：R735[医药卫生—肿瘤]