益生菌延长秀丽隐杆线虫寿命分子机制研究进展  

Advances in Molecular Mechanisms of Probiotics Extending the Lifespan of Caenorhabditis elegans

作　　者：张俊桃 赵艳梅[2] 孙天松[1] Zhang Juntao;Zhao Yanmei;Sun Tiansong(Key Laboratory of Dairy Biotechnology and Engineering,Ministry of Education,Key Laboratory of Dairy Products Processing,Ministry of Agriculture and Rural Affairs,Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering,Inner Mongolia Agricultural University,Hohhot 010018;Key Laboratory of RNA Biology,CAS Center for Excellence in Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101)

机构地区：[1]内蒙古农业大学乳品生物技术与工程教育部重点实验室、农业农村部奶制品加工重点实验室、内蒙古乳品生物技术与工程重点实验室,呼和浩特010018 [2]中国科学院生物物理研究所、中国科学院生物大分子研究中心,RNA生物学重点实验室,北京100101

出　　处：《中国食品学报》2023年第2期365-373,共9页Journal of Chinese Institute Of Food Science and Technology

基　　金：内蒙古自治区科技重大专项(2021ZD0014);财政部和农业农村部:国家现代农业产业技术体系资助。

摘　　要：益生菌通过改善宿主肠道微生态平衡,抵抗有害菌,增强宿主黏膜屏障完整性及免疫调节等多种作用机制对宿主健康产生有益作用。秀丽隐杆线虫(简称线虫),因生命周期短以及具有保守的调节宿主寿命的信号通路和宿主防御机制,而成为宿主-微生物相互作用和衰老研究的理想模型。本文总结线虫中益生菌通过作用于常见的分子信号通路,如胰岛素(IIS)、p38丝裂原激活蛋白激酶(p38 MAPK)和压力应激等,发挥抗衰老作用的研究进展,为开发益生菌菌株提供新的见解。Probiotics have beneficial effects on host health by improving intestinal microecological balance,resisting harmful bacteria,enhancing the integrity of host mucosal barrier and immune regulation.Caenorhabditis elegans(C.elegans)is widely used as an ideal model for host-microbial interaction and aging research due to its short life cycle and conserved host life-regulating signaling pathways and host defense mechanisms.This review summarized the anti-aging effects of probiotics in nematodes by acting on common molecular signaling pathways,including insulin(IIS),p38 mitogen-activated protein kinase(p38 MAPK)and stress response,and provided new insights into the development of probiotic strains.

关 键 词：益生菌 秀丽隐杆线虫 胰岛素信号通路 P38信号通路 压力应激 

分 类 号：TS201.3[轻工技术与工程—食品科学]