水相中表面活性型月桂酸催化类Mannich反应合成3-胺烷基吲哚  

Synthesis of 3-Amino Alkylated Indoles Catalyzed by Surfactant-Type Lauric Acid in Water via a Mannich-Type Reaction

作　　者：杜玉英[1] 贾璐 田福利 吕莉[1] 韩利民[1] 竺宁[1] DU Yuying;JIA Lu;TIAN Fuli;Lü Li;HAN Limin;ZHU Ning(College of Chemical Engineering,Key Laboratory of CO,Resource Utilizationat Universities of Inner Mongolia Autonomous Region,Inner Mongolia University of Technology,Hohhot O10051,China;Hainan Vocational University of Science and Technology,Haikou 571126,China)

机构地区：[1]内蒙古工业大学化工学院,二氧化碳资源化利用自治区高等学校重点实验室,呼和浩特010051 [2]海南科技职业大学,海口571126

出　　处：《内蒙古大学学报（自然科学版）》2022年第6期606-610,共5页Journal of Inner Mongolia University：Natural Science Edition

基　　金：内蒙古工业大学博士基金项目(BS2021023)。

摘　　要：在水相中、温和条件下以表面活性物质月桂酸为催化剂,通过类Mannich反应由芳香醛、吲哚和二级胺三组分合成3-胺烷基吲哚衍生物。催化剂月桂酸具有安全无毒、廉价易得、高效等优点。反应过程无需使用金属催化剂,反应条件温和、操作简便,避免了使用有机溶剂,不仅产率良好,而且具有原子经济性好(原子经济性为94.5%)、环境因子较小(环境因子为0.441)的特点。An efficient process for synthesis of 3-amino alkylated indoles from indoles,aromatic aldehydes and secondary amine was developed via a Mannich-type reaction using the surfactant-type lauric acid as catalyst in water under a mild condition.By using lauric acid as a safe,non-toxic,cheap and efficient catalyst,the synthetic process exhibited features of non-metal catalyst involved,mild condition,easy operation,and organic solvents-free,resulting in effective environmental compatibility factors of high atom economy(94.5%)and small E-factor(0.441).

关 键 词：3-胺烷基吲哚 月桂酸 酸催化 原子经济性 环境因子 

分 类 号：O621.3[理学—有机化学]