抑癌因子p14-ARF对p53-MDM2网络的影响  

The Influence of Tumor-Suppressor Factor p14-ARF on p53-MDM2 Network

作　　者：霍锐敏 李莎莎 杨红丽[1] 杨联贵[1] HUO Ruimin;LI Shasha;YANG Hongli;YANG Liangui(School of Mathematical Sciences,Inner Mongolia University,Hohhot O10021,China)

机构地区：[1]内蒙古大学数学科学学院,呼和浩特010021

出　　处：《内蒙古大学学报（自然科学版）》2023年第1期11-17,共7页Journal of Inner Mongolia University：Natural Science Edition

基　　金：国家自然科学基金(11762011);内蒙古自治区自然科学基金(2021ZD01)资助。

摘　　要：p53是一种重要的抑癌因子,可激活细胞周期阻滞、DNA损伤修复、衰老或凋亡,在细胞命运决定中起重要作用。用ATMp的表达水平代表DNA损伤强度,建立了由p14-ARF调控的p53-MDM2网络的数学模型。通过数值模拟,分析了ATMp和p14-ARF对p53-MDM2通路的影响。研究表明,较低的ATMp水平会使p53p稳定在低稳态,适当的ATMp会激活p53-MDM2网络的振荡。此外,p53p的表达水平随着p14-ARF表达水平的升高呈现出低稳态,振荡和高稳态的动力学。p53 is an important tumor suppressor, which can activate cell cycle arrest, DNA damage repair, senescence or apoptosis, and plays a very important role in cell fate determination.The level of ATMp is used to represent the intensity of DNA damage, and a mathematical model of the p53-MDM2 negative feedback network regulated by p14-ARF is established.Through numerical simulation, the influence of DNA damage intensity and p14-ARF expression level on the p53-MDM2 pathway is analyzed.The study suggest that lower ATMp level will stabilize p53p in a low steady state, and proper ATMp will activate the p53-MDM2 network oscillation.Moreover, the level of p53p will show low steady state, oscillation, and high steady state kinetics with the increase of p14-ARF expression level.

关 键 词：p14-ARF p53-MDM2网络 分岔分析 数值模拟 

分 类 号：O193[理学—数学] O29[理学—基础数学]