Targeting TRPM2- and TRPM4-extrasynaptic N-methyl-D-aspartate receptor coupling in ischemic stroke  

作　　者：Pengyu Zong Cindy X.Li Jianlin Feng Lixia Yue 

机构地区：[1]Department of Cell Biology,Calhoun Cardiology Center,UConn Health,Farmington,CT,USA

出　　处：《Neural Regeneration Research》2023年第11期2383-2384,共2页中国神经再生研究（英文版）

基　　金：National Institute of Health (R01-HL143750);American Heart Association (19TPA34890022) to LY。

摘　　要：Ischemic stroke represents a heavy burden on public health.Currently,recanalization is the only effective therapy for ischemic stroke in a small population of eligible patients.However,there is no effective adjunct medication for preventing neuron loss after reperfusion to mitigate longlasting brain injury.Extrasynaptic N-methyl-Daspartate receptors (esNMDARs) are the major cause of ischemic neuronal death.However,there is no inhibitor selectively ta rgeting esNMDARs without compromising the function of other"beneficial"syna ptic NMDARs.

关 键 词：ASPARTATE ISCHEMIC MEDICATION 

分 类 号：R743.3[医药卫生—神经病学与精神病学]