ASPARTATE

作品数：113被引量：287H指数：10
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Excitatory amino acid transporter supports inflammatory macrophageresponses
《Science Bulletin》2024年第15期2405-2419,共15页Zhending Gan Yan Guo Muyang Zhao Yuyi Ye Yuexia Liao Bingnan Liu Jie Yin Xihong Zhou Yuqi Yan Yulong Yin Wenkai Ren 
supported by the National Natural Science Foundation of China (32225047 and U22A20510);Laboratory of Lingnan Modern Agriculture Project (NT2021005);National Center of Technology Innovation for Pigs (NCTIP-XD/B13);double first-class discipline promotion project (2023B10564001)。
Excitatory amino acid transporters(EAATs) are responsible for excitatory amino acid transportation and are associated with auto-immune diseases in the central nervous system and peripheral tissues.However, the subcell...
关键词：MACROPHAGES Excitatory amino acid transporter GLUTAMATE ASPARTATE mTORC1 
Anti-N-methyl-D-aspartate receptor type autoimmune encephalitis with severe pneumonia:a case report
《World Journal of Emergency Medicine》2024年第2期142-146,共5页Yi Gu Xiandong Liu Tiancao Dong Qian Yang Xiaowei Bao Dongyang Zhao Lunxian Tang 
supported by grants from the National Natural Science Foundation of China(81970072 to LXT);the Leading Medical Talent Project of Shanghai Pudong Heath Bureau(PWRI2019-05 to LXT);the Action Plan for Scientific and Technological Innovation of Shanghai Scientific Committee of China(20Y11901200 to LXT);the Municipal Natural Science Foundation of Shanghai Scientific Committee of China(22ZR1451000 to LXT);the Key Clinical Discipline of Shanghai Pudong Heath Bureau(PWZxk2022-17 to LXT);the Clinical Peak Discipline of Shanghai Pudong Heath Bureau(PWYgf2021-03)。
Autoimmune encephalitis(AE)is a type of encephalitis caused by autoimmune disease.AE was included on a list of the first batch of 121 rare diseases published by the Chinese National Health Commission on 11^(th)May 201...
关键词：ENCEPHALITIS AUTOIMMUNE ASPARTATE 
Effects of Tribulus terrestris saponins on proliferation and invasion of A549 cells
《Journal of Hainan Medical University》2023年第23期1-6,共6页TANG Huan-huan HUANG Ya-nan LU Zai-qing ZHOU Xiang-dong ZHANG Haibin LI Qi LIU He-lu 
National Key R&D Plan(2022YFC2305004);Hainan Province Major Science and Technology Special Project(No.ZDKJ2021036);Key R&D projects in Hainan Province(No.ZDYF2020223);Hainan Province Key R&D Plan International Science and Technology Cooperation Project(GHYF2022011);Hainan Provincial Innovation Team Project(No.820CXTD448);National Natural Science Foundation of China(No.82260001,82160012)。
Objective:Tribulus terrestris saponin is a traditional Chinese medicine in China.This experiment was designed to investigate the effects of tribulus terrestris saponin on the proliferation and invasion ability of non-...
关键词：Tribulus terrestris saponin Non-small cell carcinoma Cysteinyl aspartate specific proteinase Matrix metallo-proteinase 
Targeting TRPM2- and TRPM4-extrasynaptic N-methyl-D-aspartate receptor coupling in ischemic stroke被引量：1
《Neural Regeneration Research》2023年第11期2383-2384,共2页Pengyu Zong Cindy X.Li Jianlin Feng Lixia Yue 
National Institute of Health (R01-HL143750);American Heart Association (19TPA34890022) to LY。
Ischemic stroke represents a heavy burden on public health.Currently,recanalization is the only effective therapy for ischemic stroke in a small population of eligible patients.However,there is no effective adjunct me...
关键词：ASPARTATE ISCHEMIC MEDICATION 
Identification of key residues for the activity of aspartate 4‑decarboxylase towards l‑3‑methylaspartate
《Systems Microbiology and Biomanufacturing》2023年第3期449-456,共8页Mingzhu Hao Laichuang Han Zhemin Zhou Zhongmei Liu 
the National Natural Science Foundation of China(21878125).
Aspartate 4-decarboxylase(ASD)has been modified to obtain the catalytic ability of the unnatural substrate l-3-methylaspartate.However,the mechanism remains to be clarified.In the present study,the semi-rational modif...
关键词：Aspartate 4-decarboxylase l-3-methylasparte Substrate-binging pocket Molecular dynamics simulation 
A Novel Method for the Quantitative Detection of Sericin Content in Silk Fiber Based on the Ratio of Aspartate to Alanine
《Journal of Renewable Materials》2023年第1期167-184,共18页Yanfei Feng Jiaming Lin Longxing Niu Peng Pan Xueping Liu Linling Huang Ying Guo Mingzhong Li 
supported by the National Key Research and Development Program of China(2017YFC1103602).
The development of a method for the quantitative determination of the sericin content ratio(SCR)is urgently needed for silk refining and the purification of silk fibroin for biomedical applications.In this work,a seri...
关键词：SILK sericin content amino acid analysis 
N-methyl-D-aspartate receptor functions altered by neuronal PTP1B activation in Alzheimer’s disease and schizophrenia models
《Neural Regeneration Research》2022年第10期2208-2210,共3页Alexandre F.R.Stewart Hsiao-Huei Chen 
supported by grants from the Heart and Stroke Foundation of Canada(G-13-0002596&G-18-0022157,to HHC;G-16-00014085,to AFRS);Ontario Mental Health Foundation(to HHC),the Canadian Institutes of Health Research(201610PJT#376403,to HHC;201610PJT#376503,to AFRS);the Natural Science and Engineering Research Council of Canada(RGPIN/06212-2014,to HHC;RGPIN/2016-04985,to AFRS);supported by a Mid-Career Investigator Award(grant#7506)from the Heart and Stroke Foundation of Ontario.
Glutamate is the main exc i tatory neurotransmitter in the brain and binds to two major classes of receptors,theα-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid(AMPA)and the N-methyl-D-aspartate(NMDA)receptors.U...
关键词：PTP1B ASPARTATE NMDA 
Discovery of novel aspartate derivatives as highly potent and selective FXIa inhibitors
《Journal of Chinese Pharmaceutical Sciences》2022年第10期727-737,共11页Ling Zhang Wei Chen Ningning Yao Shuzeng Hou Zhiwei Meng Yi Kong Chenzhong Liao Zhouling Xie 
National Natural Science Foundation of China(Grant No.81803352)。
As a coagulation factor in the intrinsic coagulation pathway,factor XIa(FXIa)is an effective and safe target for the development of antithrombotic drugs.Many small-molecule FXIa inhibitors have been discovered,some of...
关键词：ANTITHROMBOSIS ANTICOAGULANTS Factor XIa Bleeding risk Structure-activity relationship 
Baseline aspartate aminotransferase/alanine transaminase ratio is associated with 3-year mortality in peritoneal dialysis patients
《Chinese Medical Journal》2022年第13期1622-1624,共3页Ruoxi Liao Xueli Zhou Dengyan Ma Jing Tang Hui Zhong 
funded by the National Natural Science Foundation of China(No.82000702).
To the Editor:Peritoneal dialysis(PD)is a well-established renal replacement therapyin end-stage renal disease(ESRD)patients.Despite significant advances in technologies in recent decades,the mortality of PD patients ...
关键词：patients DIALYSIS ASPARTATE 
Aspartate transferase-to-platelet ratio index-plus: A new simplified model for predicting the risk of mortality among patients with COVID-19被引量：1
《World Journal of Gastroenterology》2022年第16期1671-1680,共10页Ali Madian Ahmed Eliwa Hytham Abdalla Haitham A Azeem Aly 
BACKGROUND Coronavirus disease 2019(COVID-19)has a spectrum of clinical syndromes with serious involvement of the lung and frequent effection of the liver and hemostatic system.Blood biomarkers are affordable,rapid,ob...
关键词：COVID-19 Aspartate transferase-to-platelet ratio index Aspartate transferase All-cause inhospital mortality Serum ferritin SARS-CoV-2 
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